In vivo Evaluation of Antiplasmodial Properties of Myosotis scorpioides L. (Boraginaceae) Extract in Albino Mice Infected with Plasmodium berghei

Abdu Zakari1, Dimas Kubmarawa2, Sani M. Isyaka1, Christiana A. Kendeson1, Elisha B. Baba3
1Department of Chemical Sciences, Federal University Kashere, P.M.B 0182, Gombe, Nigeria.
2Department of Chemistry, Modibbo Adama University of Technology Yola, P.M.B 2076 Yola, Nigeria.
3Department of Pharmacology, National Institute for Pharmaceutical Research and Development (NIPRD) Idu-Abuja, Nigeria.

Corresponding Author: [email protected] ; Tel: +2348136202778
Recieved Date: February 11, 2018; Accepted Date: April 07, 2018; Published Date: 07 April 2018
Citation: Zakari A, Kubmarawa D, Isyaka SM, Kendeson CA, Baba EB. In vivo Evaluation of Antiplasmodial Properties of Myosotis scorpioides L. (Boraginaceae) Extract in Albino Mice Infected with Plasmodium bergei. Trop J Nat Prod Res. 2018; 2(4):198-202.  https://doi.org//10.26538/tjnpr/v2i4.8
Copyright: © 2018 Zakari et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
ABSTRACT

Myosotis scorpioides L commonly called water forget-me-not or true forget-me-not has been claimed by Traditional Medicine Practitioners (TMP) in Adamawa State to cure malaria. It is a herbaceous perennial flowering plant in the borage family (Boraginaceae). The present study was undertaken to scientifically verify the claimed ethnomedicinal use of the plant as antimalarial. The crude powdered sample (whole plant) of Myosotis scorpioides was extracted with methanol in a Soxhlet extractor. The concentrated extract was screened for the presence of secondary metabolites, tested for the median lethal dose (LD50) and antimalarial activity using Swiss albino mice. The result of the phytochemical screening indicated the presence of alkaloids, terpenes, tannins, flavonoids, saponins and anthraquinones. The result of the suppressive test (early malaria infection) showed a significant percentage suppression compared to the control with values of 49.91%, 56.72%, and 65.63% at the doses of 100 mg/kg, 150 mg/kg, and 250 mg/kg, respectively. The result of the prophylactic (residual malaria infection) tests showed a significant level of inhibition compared to the control (43.22%, 52.45%, and 85.70%) for the three doses. The curative (established malaria infection) tests also showed a significant level of parasite suppression compared to the control with percentage suppression of 66.73%, 70.20%, and 73.96% at 100, 150, and 250 mg/kg, respectively. The present study has validated the use of Myosotis scorpioides as remedy to malaria infection by the traditional medicine practitioners in Adamawa, State Nigeria.

Keywords: Antimalarial, Myosotis scorpioides, Plasmodium berghei, Albino Mice.
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ISSN: 2616-0684 (Print)
ISSN: 2616-0692 (Online)
DOI: 10.26538/tjnpr

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