Ameliorative effect of coconut oil (Cocos nucifera) on the testes of Norwegian rats intoxicated with untreated crude refinery effluents

Sese-Owei Ekaye1, Edwin A. Uwagie-Ero2*, Cosmos O. Aghayedo1
1Department of Animal and Environmental Biology, Faculty of Life Sciences, University of Benin, Benin City, Nigeria.
2Department of Veterinary Surgery, Faculty of Veterinary Medicine, University of Benin, Benin City, Nigeria.

Corresponding Author: [email protected]; Tel: +2348033977590
Recieved Date: March 07, 2018; Accepted Date: March 31, 2018; Published Date: 07 April 2018
Citation: Ekaye S, Uwagie-Ero EA, Aghayedo CO. Ameliorative effect of coconut oil (Cocos nucifera) on the testes of Norwegian rats intoxicated with untreated crude refinery effluents. Trop J Nat Prod Res. 2018; 2(4):171-178. https://doi.org//10.26538/tjnpr/v2i4.4
Copyright: © 2018 Ekaye et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
ABSTRACT

The study was aimed at determining the effects of untreated refinery effluent on the spermatogenic status of the testes in Norwegian rats and possible ameliorative effects of coconut oil. Thirty Norwegian rats were used for the study, divided into 3 groups of 10 animals each. Group 1 were given feed and drinking water, group 2 were given feed, drinking water and 2 mL of 100% of the untreated refinery effluent, group 3 were given feed, drinking water, 2 mL of 100% of refinery effluent and 2 mL of Coconut oil continuously for 9 weeks. At 3 weeks intervals, two rats were sacrificed from each group. Testicular tissues were harvested and analyzed. Treatment was discontinued after nine weeks. Groups 2 and 3 were re-designated groups 5 and 6, left for a period of 21 days without treatment. At the 21st day, testicular tissues were collected and analyzed. There was a significant increase (P > 0.05) in body and organ weight of treated rats compared to control. Organ morphology varied from control but was not statistically defined. Lead and chromium concentrations in testes were significantly different (P > 0.001) in effluent treated rats. Histopathology of the gonads showed evidence of pathologies in rats treated with effluent only compared to control and ameliorated groups. Testes of rats treated with coconut oil revealed normal spermatogenic architecture during and after exposure to refinery effluent. Coconut oil was effective in ameliorating the deleterious effects of untreated refinery effluent on the testicles of intoxicated Norwegian rats.

Keywords: Refinery effluents, toxicity, testis, coconut oil, amelioration.
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ISSN: 2616-0684 (Print)
ISSN: 2616-0692 (Online)
DOI: 10.26538/tjnpr

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