In Vivo Antiplasmodial and Toxicological Effects of Extracts of Fruit Pulp of Chrysophyllum albidium G. Don (Sapotaceae)

Chibueze P. Ihekwereme*, Chinelo O. Melidem, Ijeoma C. Maduka, Jude N. Okoyeh
Department of Pharmacology & Toxicology, Faculty of Pharmaceutical Sciences, Nnamdi Azikiwe University, Awka, Nigeria.
Corresponding Author: [email protected] ; Tel: +234 7089817404
Recieved Date: December 30, 2017; Accepted Date: March 06, 2018; Published Date: 07 March 2018
Citation: Ihekwereme CP, Melidem CO, Maduka IC, Okoyeh JN. In Vivo Antiplasmodial and Toxicological Effects of Extracts of Fruit Pulp of Chrysophyllum albidium G. Don (Sapotaceae). Trop J Nat Prod Res. 2018; 2(3):126-131.  https://doi.org//10.26538/tjnpr/v2i3.5
Copyright: © 2018 Ihekwereme et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
ABSTRACT

Plant parts of Chrysophyllum albidium is reported to possess antimalarial properties. However, knowledge gaps still exist in the antimalarial efficacy and safety of some solvent fractions of the fruit pulp. The aim of this study is to explore the antimalarial and toxicological potentials of the methanol extract of the pulp of C. albidum. Prophylactic and curative antiplasmodial activities of the methanol extract of the fruit pulp were evaluated using rodent malaria model. Repeated dose toxicity studies were conducted for 28 days using OECD 407 guidelines. The effect of the extract on animal weight, hematological and biochemical parameters were estimated. The oral acute toxic dose of the pulp extract was beyond 5000 mg/kg. The extract demonstrated prophylactic activities at 100 mg/kg (27.94%) and 200 (67.79%) mg/kg doses. The highest curative antimalarial activity was at 15 mg/kg dose on day 4 (72.43 %) and day 7 (83.80 %). The repeated dose toxicity assay did not show that the extract is harmful to the experimental animals. The extract reduced the PCV and hemoglobin level at 15 and 50 mg/kg dose, but not at 150 mg/kg. The Alanine aminotransferase (ALT) and Aspartate aminotransferase (AST) levels significantly decreased at the end of the study. This study used a murine model of malaria to demonstrate that the methanol extract of the fruit pulp of C. albidum possesses prophylactic and curative properties. The repeated dose toxicity study did not show any toxicity to the experimental animals.

Keywords: Chrysophyllum albidium, Parasitemia, Antimalarial, Antiplasmodium.
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ISSN: 2616-0684 (Print)
ISSN: 2616-0692 (Online)
DOI: 10.26538/tjnpr
ISI Impact Factor: 0.562
Index Copernicus Value (ICV) for 2017: 59.83

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