Development of Okra-Based Antidiabetic Nutraceutical Formulation from Abelmoschus esculentus (L.) Moench (Ex-maradi Variety)

Ismaila Muhammad1, Ibrahim K. Matazu1, Ibrahim A. Yaradua1, Salahuddeen Yau1, Abdullahi Nasir1, Suleman L. Bilbis2, Yahya A. Abbas2*
1Department of Biochemistry, Faculty of Natural and Applied Sciences, Umaru Musa Yaradua University, P.M.B. 2218 Katsina, Nigeria.
2Department of Biochemistry, Faculty of Science, Usmanu Danfodiyo University P.M.B. 2346 Sokoto, Nigeria.

Corresponding Author: [email protected]; Tel: +234 8035052927
Recieved Date: December 26, 2017; Accepted Date: January 30, 2018; Published Date: 08 February 2018
Citation: Muhammad I, Matazu KI, Yaradua AI, Yau’ S, Nasir A, Bilbis LS, Abbas AY. Development of Okra-Based Antidiabetic Nutraceutical Formulation from Abelmoschus esculentus (L.) Moench (Ex-maradi Variety). Trop J Nat Prod Res. 2018; 2(2):80-86.
Copyright: © 2018 Muhammad et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

Diabetes mellitus is a complex metabolic disorder that is considered a worldwide epidemic and is associated with the development of many complications. Okra fruit is rich in fiber and other medicinal phytochemicals, hence could be a potential source for the development of antidiabetic nutraceutical. Subsequent to our earlier reports on the antidiabetic effects of various parts of ex-maradi okra fruit, the current study was designed to develop appropriate formulation from the fruit seeds and peels. Various proportions of the powdered seeds and peels samples were thoroughly mixed in a ratio of 90:10; 80:20; 70:30; 60:40, 50:50%, respectively and vice-versa. The proximate composition and some functional properties viz: Antioxidant Capacity (AC), Water Adsorption Capacity (WAC), Oil Adsorption Capacity (OAC), Glucose Adsorption Capacity (GAC), Glucose Dialysis (GD), and Glucose Dialysis Retardation Index (GDRI) of each formulation were evaluated in-vitro. The results revealed that 10:90% (Seeds:Peels) formulation exhibited the highest significant (P < 0.05) percentage of Crude ash, fibre, and protein content; it also showed highest significant (P < 0.05) values for AC, WAC, OAC, GAC and GDRI as well as the lowest value for GD. Conclusively, the study showed that the 10:90% (Seeds:Peels) formulation has a reduction effect on the rate of glucose adsorption and diffusion and thus can retard increase in postprandial blood glucose level than the other combinations. Therefore, this combination was found to be the most suitable for the development of okra-based antidiabetic nutraceutical formulation for the management of diabetes mellitus.

Keywords: Diabetes Mellitus, Abelmoschus esculentus, Functional properties, Antioxidants, Nutraceutical.
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ISSN: 2616-0684 (Print)
ISSN: 2616-0692 (Online)
DOI: 10.26538/tjnpr
Index Copernicus Value (ICV) for 2017: 59.83

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