Anti-seizure activity of Extract of Jatropha gossypiifolia Linn (Euphorbiaceae)

Abdullahi H. Yaro*, Musa Aliyu, Kamaludeen Garba, Sani Hassan
Department of Pharmacology and Therapeutics, Bayero University, Kano, Nigeria
Corresponding Author: [email protected]; Tel: +2348061556597
Recieved Date: January 13, 2018; Accepted Date: February 02, 2018; Published Date: 08 February 2018
Citation: Yaro AH, Aliyu M, Garba K, Hassan S. Anti-seizure activity of Extract of Jatropha gossypiifolia Linn (Euphorbiaceae). Trop J Nat Prod Res. 2018; 2(2):99-102. https://doi.org//10.26538/tjnpr/v2i2.8
Copyright: © 2018 Yaro et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
ABSTRACT

The leaves of Jatropha gossypiifolia has been widely used for the treatment of epilepsy and childhood convulsions in ethnomedicinal practice of Northern Nigeria. In this study, we investigated the anti-seizure claim of this plant part using established scientific protocols. Phytochemical screening and acute toxicity evaluation of the methanol leaf extract were performed while maximal electroshock-induced seizures in cockerels (MEST), pentylenetetrazole (PTZ), strychnine (STN) and 4-aminopyridine (4-AP) induced seizure models were employed in mice. The methanol leaf extract contains cardiac glycosides, steroids, triterpenes, tannins and flavonoids, while the median lethal dose of the extract was estimated to be 1131 mg/kg. In the anti-seizure studies, the extract at all the tested doses (75, 150 and 300 mg/kg) did not delay the recovery time of convulsed cockerels in MEST model nor delay the mean onset of seizures in PTZ and 4-AP models in mice in comparison with controls. Conversely, the extract at 150 mg/kg dose significantly (p ? 0.05) delayed the mean onset of seizures in mice in STN model compared to control treatments. In conclusion, this study provided the possible pharmacological basis for the use of Jatropha gossypiifolia leaf in treating seizure conditions.

Keywords: Seizure, Jatropha gossypiifolia, Strychnine, 4-aminopyridine.
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ISSN: 2616-0684 (Print)
ISSN: 2616-0692 (Online)
DOI: 10.26538/tjnpr
ISI Impact Factor: 0.562
Index Copernicus Value (ICV) for 2017: 59.83

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