Antidepressant Effect of Methanol Stem Bark Extract of Adansonia digitata L. (Malvaceae) in Mice

Aishatu Shehu1*, Mohammed G. Magaji1, Jamilu Yau 1, Bukhari Mahmud1, Abubakar Ahmed2
1Department of Pharmacology and Therapeutics, Ahmadu Bello University, Nigeria
2Department of Pharmacognosy and Drug Development, Ahmadu Bello University, Nigeria


Corresponding Author: [email protected]; Tel: +234-803-6028298
Recieved Date: December 22, 2017; Accepted Date: January 30, 2018; Published Date: 08 February 2018
Citation: Shehu A, Magaji MG, Yau J, Mahmud B, Ahmed A. Antidepressant Effect of Methanol Stem Bark Extract of Adansonia digitata L. (Malvaceae) in Mice. Trop J Nat Prod Res. 2018; 2(2):87-91.  https://doi.org//10.26538/tjnpr/v2i2.6
Copyright: © 2018 Shehu et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
ABSTRACT

Adansonia digitata (Malvaceae) is a plant native to Africa with all its parts used extensively since ancient times in traditional medicine for different purposes including psychiatric disorders. The plant has been used ethnomedicinally as a remedy for depression. The aim of the study was to investigate the antidepressant activity of the methanol stem bark extract of A. digitata. Phytochemical screening and acute oral toxicity (LD50) study were done using standard procedures. Antidepressant activity of the extract (250-1000 mg/kg) was evaluated using tail suspension test (TST) and forced swim test (FST) in mice. Tests for motor co-ordination deficit and stimulant activity were evaluated using beam walking assay (BWA) and open field test (OFT), respectively. The effect of the methanol stem bark extract of A. digitata was tested using the novel object recognition task (NORT). The phytochemical screening of the extract showed the presence of steroids, tannins, flavonoids, alkaloids and saponins. The LD50 was found to be greater than 5000 mg/kg orally. The extract significantly (P < 0.01) and dose-dependently decreased the duration of immobility in the TST and FST. There was no significant change in the number of lines crossed and on the number of foot slips in the OFT and BWA, respectively. The extract showed no significant effect on cognition in the NORT. In conclusion, the methanol stem bark extract of A. digitata possesses antidepressant activity.

Keywords: Adansonia digitata, depression, tail suspension test, forced swim test.
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ISSN: 2616-0684 (Print)
ISSN: 2616-0692 (Online)
DOI: 10.26538/tjnpr

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