Neuroprotective Potentials of Alstonia boonei Extracts on Biochemical Markers of Brain Integrity in Experimental Rats

Egba S. Ikechukwu1, Okonkwo C. Onyinye2, Ogbodo J. Onyebuchi3*, Ezeh V. Nzubechukwu1

1Department of Biochemistry, College of Natural Sciences, Michael Okpara University of Agriculture Umudike, Abia State, Nigeria
2Department of Biochemistry, Faculty of Basic Medical Sciences, University of Calabar, Cross Rivers State, Nigeria
3Department of Science Laboratory Technology University of Nigeria, Nsukka, Nigeria

Corresponding Author: [email protected]; Tel: +2348037331402
Recieved Date: 20 December 2020; Accepted Date: 19 June 2021; Published Date: 01 July
Citation: Ikechukwu ES, Onyinye OC, Onyebuchi OJ, Nzubechukwu EV. Neuroprotective Potentials of Alstonia boonei Extracts on Biochemical Markers of Brain Integrity in Experimental Rats. Trop J Nat Prod Res. 2021; 5(6):1106-1109.
© 2021 Ikechukwu et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
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Alstonia boonei has been proven to be a valuable source of bioactive components. Over time, these have been used in the management of various medical conditions. This work investigated the effects of Alstonia boonei on neuroprotective parameters/markers (vitamin E, adenine deaminase and acetylcholinesterase) in mercury chloride-induced cognitive impairment and associated oxidative damages in rats. A total of 16 adult Wistar rats (male) weighing between 100 and 130 g was divided into four groups. Group 1: normal control, Group 2: mercury (II) chloride, Group 3: mercury (II) chloride + Diazepam 5 mg/kg and Group 4: mercury (II) chloride + plant extract 400 mg/kg. The result shows that neurotoxicant; mercury (II) chloride (4 mg/kg body weight; orally) caused a significant decrease in vitamin E concentration and adenine deaminase activity and increased acetycholine esterase activity, the treatment with the standard drug and A. boonei extract successfully reversed the deleterious effects of the toxicant by increasing vitamin E concentration in both the cerebrum and cerebellum, reducing acetylcholine esterase activity in the cerebrum. A. boonei also significantly (p < 0.05) increased adenine deaminase activity in the cerebrum. This indicates that the A. boonei extract may possess potent neuroprotective agents whose full potentials are yet to be exploited.

Keywords: Cognitive, Neuroprotective parameters, Alstonia boonei, Acetylcholinesterase, Wistar rats 
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ISSN: 2616-0684 (Print)
ISSN: 2616-0692 (Online)
DOI: 10.26538/tjnpr
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