Evaluation of Antidiabetic, Phytochemical and Acute Toxicity of the Methanol Seed Extract of Senna occidentalis Linn 

Fave Y. Tata1*, Fatima M. Danlamido1, Hafsat A. Sa’ab1, Musa A. Audu1, Abdulqadir B. Bababe2
1Department of Pharmacology and Toxicology, Faculty of Pharmacy, University of Maiduguri, Maiduguri, Nigeria
2Department of Pharmaceutical Chemistry, Faculty of Pharmacy, University of Maiduguri, Maiduguri, Nigeria



Corresponding Author: [email protected]; Tel: +23407063072245
Recieved Date: 15 December 2020; Accepted Date: 07 June 2021; Published Date: 01 July
Citation: Tata FY, Danlamido FM, Sa’ab HA, Audu MA, Bababe AB. Evaluation of Antidiabetic, Phytochemical and Acute Toxicity of the Methanol Seed Extract of Senna occidentalis Linn. Trop J Nat Prod Res. 2021; 5(6):1101-1105. http://www.doi.org/10.26538/tjnpr/v5i6.20
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 © 2021 Tata et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
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ABSTRACT

Diabetes mellitus is one of the major chronic medical conditions. Many medicinal plants have 
demonstrated antidiabetic effect. The study evaluated the phytochemical constituents, acute toxicity and antidiabetic activity of the methanol seed extract of Senna occidentalis. Six groups of Wistar rats were used for the antidiabetic study. Group 1 was used as normal control while groups 2 and 3 were used for metformin and insulin as standard controls respectively. Groups 4, 5 and 6 were administered 200, 400 and 800 mg/kg of the methanol seed extract of S. occidentalis respectively through oral intubation. The study revealed the presence of carbohydrates, cardenolites, anthraquinones, flavonoids, tannins and triterpenoids. Alkaloids and saponins were not detected. The acute toxicity was greater than 4000 mg/kg body weight with no death during the 10 days observation after oral administration of the extract. The plant extract showed mild hypoglycaemic activity at the dose of 800 mg/kg at 12 hours by 3% and by 21% at 24 hours, slight decrease in blood glucose level was observed at 400 mg/kg by 2% and by 5% at 6 and 24 hours respectively. However, the extract showed no activity at 200 mg/kg throughout the study. The positive control (insulin) reduced the blood glucose level significantly by 65%, 57% and 36% at 3, 6 and 12 hours respectively but hypoglycaemic effect demonstrated by metformin throughout the study. The methanol seed extract of S. occidentalis showed mild hypoglycaemic activity. The extract contains phytochemical constituents that might be responsible for its antidiabetic activity.

Keywords: Alloxan monohydrate, Acute toxicity, Diabetes, Methanol, Senna occidentalis.
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ISSN: 2616-0684 (Print)
ISSN: 2616-0692 (Online)
DOI: 10.26538/tjnpr
Index Copernicus Value (ICV) for 2017: 59.83
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