Antihyperlipidemic Effects of Silver Nanoparticles Synthesized from Ventilago maderaspatana Leaf Extract on Streptozotocin-Induced Albino Rats

Periyasamy Karuppannan1, Kaliyaperumal Saravanan1*, Chukwuebuka Egbuna2,3,4*, Chukwuemelie Z. Uche5, Kingsley C. Patrick-Iwuanyanwu2,3, Johra Khan6,7
1PG and Research Department of Zoology, Nehru Memorial College (Autonomous), Puthanampatti – 621 007 Affiliated to Bharathidasan University, Tiruchirappalli, Tamil Nadu, India
2Africa Centre of Excellence for Public Health and Toxicological Research (ACE-PUTOR), Nutritional Biochemistry/Toxicology Unit, University of Port Harcourt, PMB, 5323 Port Harcourt, Choba, Nigeria
3Department of Biochemistry, Faculty of Science, University of Port Harcourt, Port Harcourt, Nigeria
4Department of Biochemistry, Faculty of Natural Sciences, Chukwuemeka Odumegwu Ojukwu University, Anambra, State, Nigeria
5Department of Medical Biochemistry and Molecular Biology, Faculty of Basic Medical Sciences, University of Nigeria, Enugu Campus, Nigeria
6Department of Medical Laboratory Sciences, College of Applied Medical Sciences, Majmaah University, Majmaah, 11952, Saudi Arabia
7Health and Basic Sciences Research Center, Majmaah University, Majmaah, 11952, Saudi Arabia

Corresponding Author: [email protected]; [email protected]; Tel: +919360313909; +2347039618485
Recieved Date: 22 April 2021; Accepted Date: 14 June 2021; Published Date: 01 July
Citation: Karuppannan P, Saravanan K, Egbuna C, Uche CZ, Patrick-Iwuanyanwu KC, Khan J. Antihyperlipidemic Effects of Silver Nanoparticles Synthesized from Ventilago maderaspatana Leaf Extract on Streptozotocin-Induced Albino Rats. Trop J Nat Prod Res. 2021; 5(6):1066-1071.
 © 2021 Karuppannan et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
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An abnormally high presence of lipid in human blood is a prelude for the emergence of cardiovascular complications. In this study, effort was made to elucidate the effect of silver nanoparticles (AgNPs) produced through the help of Ventilago maderaspatana on the hyperlipidemic conditions in streptozotocin (STZ)-induced Wistar rats. AgNPs were synthesized biologically using ethyl acetate leaf extract of V. maderaspatana. The synthesis of AgNPs was confirmed when the color of the solution turned dark brown following the addition of V. maderaspatana ethyl acetate leaf extract. To confirm further, UV-Vis spectroscopy analysis was conducted which gave a peak at 430 nm. The results obtained from the FT-IR studies shows that the compounds in the plant extract may have influenced the formation of AgNPs. The result obtained from further characterization showed that the synthesized nanoparticles were spherical and ranged between 10-50 nm. The XRD study indicates crystal nature of the particles with the size of 50nm. After the injection of STZ, the lipid profiles were altered abnormally. This can be found in group II rats (hyperlipidemic control) which had the highest level of serum total cholesterol (189.1 ± 0.80 mg/dL), triglyceride (177.9 ± 0.88 mg/dL), VLDL-c (42.5 ± 1.80 mg/dL), and LDL-c (55.2 ± 3.83 mg/dL) with the exception of HDL-c which was found low (10.4 ± 1.04 mg/dL). However, hyperlipidemic groups treated with AgNPs recorded low levels of cholesterols. Based on this, it can be concluded that biosynthesized AgNPs could be helpful in lowering cholesterol level.

Hyperlipidemia, Cardiovascular diseases, Antihyperlipidemic activity, Ventilago maderaspatana, Silver nanoparticles, Biosynthesis.
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ISSN: 2616-0684 (Print)
ISSN: 2616-0692 (Online)
DOI: 10.26538/tjnpr
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