Effect of Pulutan (Urena lobata) Leaf Extract on Blood Glucose Level, Hemoglobin and Body Growth of Zebra Fish (Danio rerio) Exposed to Malathion

Yudi Purnomo*, Iqbal A. Pamungkas, Mita Sofiani, Sumanjaya Pratama
Faculty of Medicine University of Islamic malang, Kota Malang, Jawa Timur 65144, Indonesia



Corresponding Author: [email protected]; Tel: +628123354124
Recieved Date: 23 January 2021; Accepted Date: 20 June 2021; Published Date: 01 July
Citation: Purnomo Y, Pamungkas IA, Sofiani M, Pratama S. Effect of Pulutan (Urena lobata) Leaf Extract on Blood Glucose Level, Hemoglobin and Body Growth of Zebra Fish (Danio rerio) Exposed to Malathion. Trop J Nat Prod Res. 2021; 5(6):1034-1038 http://www.doi.org/10.26538/tjnpr/v5i6.9
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© 2021 Purnomo et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
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ABSTRACT

Pulutan (Urena lobata) is a medicinal plant having antioxidant activity. However, their potency to inhibit the adverse effects of malathion has not been evaluated. The study aims to examine U. lobata leaves extract on blood glucose level, haemoglobin, and body growth of Danio rerio exposed to malathion. The study used juvenile and adult of D. rerio which were divided into five groups (n=5). The leaves of U. lobata were extracted by the decoction method. The D. rerio was administered with extract 125-500 mg/L for 40 days concomitantly with malathion 2.5-5 mg/L. Blood glucose level and haemoglobin were measured using a commercially available glucometer and Hb-meter, respectively. Meanwhile, the body weight and length was measured using a balance scale and a ruler, respectively. All data were expressed as the mean ± SD and analyzed with one-way ANOVA followed by LSD test. The administration of U. lobata extract increased the body weight by about 40-90% (p<0.05) on juveniles D. rerio, while no changes were observed in adults, whereas there was a 20% increase in body length for both juvenile and adult D. rerio. The blood glucose level was decreased by 40-60% (p<0.05) for juveniles given U. lobata, meanwhile in adult D. rerio, it was reduced by 50-60%. U. lobata reduced the decrease of hemoglobin levels by 10-40% in juvenile D. rerio and 10-30% in adult. U. lobata extract reduced the decrease in body growth and haemoglobin level, and prevented blood glucose level increase.

Keywords: Endocrine disruptor, Herbs, Hormone, Pesticides.
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ISSN: 2616-0684 (Print)
ISSN: 2616-0692 (Online)
DOI: 10.26538/tjnpr
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