Evaluation of In Vivo Anti-dyslipidemic Activity of the Combination of Andrographis paniculata Extract and Ipomea batatas Leaf Extract 

Ni K. Warditiani*, Pande M.N.A. Sari, Cokorda I.S. Arisanti, I Gusti N.J.A. Prasetia, Dewa A. Swastini, Putu S. Yustiantara, I Made A.G. Wirasuta
Department of Pharmacy, Mathematics and Natural Science Faculty, Udayana University, Indonesia
Corresponding Author: [email protected]; Tel: +6281236463040
Recieved Date: 18 May 2021; Accepted Date: 21 June 2021; Published Date: 01 July
Citation: Warditiani NK, Sari PMAA, Arisanti CIS, Prasetia IGNJA, Swastini DA, Yustiantara PS, Wirasuta IMAG. Evaluation of In Vivo Anti-dyslipidemic Activity of the Combination of Andrographis paniculata Extract (APE) and Ipomea batatas Leaf Extract (IBE). Trop J Nat Prod Res. 2021; 5(6):1014-1018 http://www.doi.org/10.26538/tjnpr/v5i6.5
Copyright:
© 2021 Warditiani et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Visit for more related articles at  Tropical Journal of Natural Product Research




ABSTRACT

Andrographis paniculata and Ipomea batatas are widely found in Indonesia, either wild or cultivated. Both plants contain some bioactive compounds, mainly andrographolides and anthocyanins. These compounds possess blood lipid reducing property through their ability to lower total cholesterol (TC), triglycerides (TG), low-density lipoprotein (LDL-C) and increase high-density lipoprotein cholesterol (HDL-C) levels. The purpose of this study was to evaluate the potential anti-dyslipidemic potency of the combination of A. paniculata Extract (APE) and I. batatas Leaf Extract (IBE) in rats. Plants were extracted, and the levels of andrographolide and total flavonoid content (TFC) from each extract were measured. The extracts were administered to the dyslipidemic rats. The blood lipid levels and histopathology of the aortic organs were observed. The obtained data were analyzed statistically with one-way ANOVA and with the biplot and multivariate analysis. The results showed that the APE, IBE, APE, and IBE combinations improved the blood lipid profiles and prevented fatty plaque accumulations in rat aortas. The anti-dyslipidemic ability may be due to the presence of andrographolide and flavonoid compounds in the extract. The correlation matrix plot analysis showed a linear relationship to the lipid profile of all treatment groups. Multivariate analysis of anti-dyslipidemic activity can help determine the most optimal effect in lowering blood lipid levels. The combination of APE and IBE provides the most optimal activity because it decreases TC and LDL-C. This combination has a protective effect on the aorta, thereby preventing atherosclerosis.

Keywords: Anti-dyslipidemic, Andrographis paniculata, combination, extract, Ipomea batatas
Back to Articles

ISSN: 2616-0684 (Print)
ISSN: 2616-0692 (Online)
DOI: 10.26538/tjnpr
Index Copernicus Value (ICV) for 2017: 59.83
Scopus citescore 0.3 (2020)

Indexing & Abstracting

citescore 0.3 (2020)

j-gate logo

International Innovative Journal Impact Factor

African Index Medicus

CAS

Index Copernicus International

Creative Commons License
This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License

Crossref Content Registration logo

WorldCat Discovery Service

Geneva Foundation for Medical Education and Research