Antioxidant Activity of Some Nigerian Medicinal Plants Used in Malaria Treatment

Oluwafunke O. Oribayo1, Mbang A. Owolabi1*, Grace E. Ukpo1, Francis O. Shode2
1Natural Product Group, Department of Pharmaceutical Chemistry, Faculty of Pharmacy, College of Medicine Campus, University of Lagos, Nigeria. 
2Department of Biotechnology and Food Technology, Faculty of Applied Sciences, Durban University of Technology, South Africa.

Corresponding Author: [email protected] ; Tel: +234 802 943 8968
Recieved Date: November 17, 2017; Accepted Date: December 22, 2017; Published Date: 07 January 2018
Citation: Oribayo OO, Owolabi MA, Ukpo GE, Shode FO. Antioxidant activity of some Nigerian medicinal plants used in malaria treatment. Trop J Nat Prod Res. 2018; 2(1):18-22.  https://doi.org//10.26538/tjnpr/v2i1.4
Copyright: © 2018 Oribayo et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
ABSTRACT

Free radicals are reactive molecules associated with many diseases including malaria; causing complications. Thus, the need to explore compounds with free radical scavenging properties. Methanol extracts of the leaves of three medicinal plants (A. barteri, O. basilicum and H. indicum) used in Nigerian folkloric medicine for the treatment of malaria were evaluated for their antioxidant activty, total phenol and flavonoid contents. The antioxidant activity evaluation included various radicals or oxidation systems - ferric-reducing antioxidant power (FRAP), 2, 2'-azinobis-(3-ethylbenzthiazoline-6-sulfonate) radical  (ABTS), and oxygen radical absorbance capacity (ORAC) assays. Total phenol and flavonoid contents were also evaluated. The leaves of A. barteri showed the highest levels of total phenol (222.30 ± 5.48 mg gallic acid equivalent/g), flavanol (22.90 ± 0.15 mg catechin equivalent/g) and flavonol contents (93.32 ± 2.80 mg quercetin equivalent/g) compared to O. basilicum and H. indicum. The antioxidant activity of these plants increased with increase in their total phenol and flavonoid contents. The order of the antioxidant activity of the plants was A. barteri > O. basilicum > H. indicum. These results suggest that the leaves of these plants contain polyphenols and could serve as potential sources of antioxidants which could be explored as therapeutic agents in the attenuation of free radical in malaria infection. 

Keywords: Alafia barteri, Ocimum basilicum, Heliotropium indicum, antioxidant activity, free radical, malaria.
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