Selenium Treatment Ameliorates Experimentally Induced Diarrhoea in Albino Rats

Olasupo S. Adeniyi 1*, Jemila O. Musa2, Joy O. Siyaka2, James Omale2
1Department of Human Physiology, Faculty of Basic Medical Sciences, Kogi State University, Anyigba, Kogi State, Post code 272012, Nigeria. 
2Department of Biochemistry, Faculty of Natural Science, Kogi State University, Anyigba, Kogi State, Post code 272012, Nigeria.

Corresponding Author: [email protected]; Tel: +2348051980450
Recieved Date: December 15, 2017; Accepted Date: January 04, 2018; Published Date: 07 January 2018
Citation: Adeniyi SO, Musa OJ, Siyaka OJ, Omale J. Selenium Treatment Ameliorates Experimentally Induced Diarrhoea in Albino Rats. Trop J Nat Prod Res. 2018; 2(1):47-50.  https://doi.org//10.26538/tjnpr/v2i1.10
Copyright: © 2018 Adeniyi et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
ABSTRACT

Diarrhoea is one of the leading causes of death in children worldwide, accounting for 1 out of every 9 deaths in children. Therefore, in an attempt to tackle this disease, we investigated the effects of selenium on experimentally induced diarrhoea in animals. Female albino rats weighing 100 - 150 g were used and diarrhoea was induced by oral administration of castor oil, after which the animals were treated with 100 or 200 µg/kg selenium orally to investigate its effect on the number of wet feaces output. Experiments on intestinal enteropooling and intestinal motility of activated charcoal meal were also carried out. The two doses of selenium (100 and 200 µg/kg) significantly (P < 0.01) reduced the number of wet feaces and also significantly (P < 0.001) reduced the volume of intestinal fluid content, with 200 µg/kg producing 43.81% inhibition of fluid content, while the standard drug loperamide caused 54.30% inhibition. Furthermore, 100 µg/kg and 200 µg/kg selenium significantly (P < 0.001) reduced intestinal motility; producing 28.49% and 29.91% motility inhibition respectively with respect to control, while atropine inhibited intestinal movement by 49.2% with reference to control. In conclusion, selenium possesses anti-diarrhoeal effects through anti-secretory and anti-motility mechanisms.

Keywords: Diarrhoea, Selenium, Anti-secretory, Anti-motility.
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