Combinatorial Chemistry and Natural Product: Recycling the Past in the Present

Osayemwenre Erharuyi (Ph.D) and Abiodun Falodun
Natural Product Research Group &Department of Pharmaceutical Chemistry, Faculty of Pharmacy, University ofBenin, PMB 1154, Benin city, Nigeria
Corresponding Author: [email protected]; Tel: +234 80 62355972
Recieved Date: December 20, 2017; Accepted Date: January 06, 2018; Published Date: 07 January 2018
Citation: Erharuyi O and Falodun A. Combinatorial Chemistry and Natural Product: Recycling the Past in thePresent. Trop J Nat Prod Res. 2018; 2(1): 1-2. https://doi.org//10.26538/tjnpr/v2i1.1
Copyright: Copyright: © 2018 Erharuyi and Falodun. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
ABSTRACT

Historically, natural products from microbial, marine, plant and animal sources have provided a useful starting point for the development of important drugs. For example, the antimalarial - quinine and artemisinins, the opioid analgesics - morphine, the antineoplastic -paclitaxel, the antibacterial – penicillins, the anticancer and antiviral – cytarabine, just to mention a few, are derived from natural products. Despite these many successes, the discovery of drugs from natural products is a time- and resource-intensive endeavour. Therefore, scientists have devised several other approaches for the discovery of therapeutically useful molecules. One of such approaches is combinatorial chemistry.

Keywords: Natural Products, Combinatorial libraries, Synthesis, High-throughput screening. 
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