Fear and Anxiety Behaviour In Mice Was Attenuated Following Chronic Consumption of Musa paradisiaca L. (Musaceae)

Peter Erigbali1*, Eme Osim2, Ofem Ofem2
1Department of Physiology, Niger Delta University, Amassoma, Bayelsa State, Nigeria. 2Department of Physiology, University of Calabar, Calabar, Nigeria.
Corresponding Author: [email protected]; Tel: +2348033258343
Recieved Date: October 08, 2017; Accepted Date: October 27, 2017; Published Date: 05 November 2017
Citation: Erigbali P, Osim E, Ofem O. Fear and Anxiety Behaviour In Mice Was Attenuated Following Chronic Consumption of Musa paradisiaca. Trop J Nat Prod Res. 2017; 1(5):223-226. doi.org/10.26538/tjnpr/v1i5.10 https://doi.org//10.26538/tjnpr/v1i5.10
Copyright: © 2017 Erigbali et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
ABSTRACT

Emotions are delicate phenomenon that can affect the whole livelihood, yet to control them physiologically is quite difficult perhaps owing to the paucity in connections between limbic system and neocortex. Many people have devised ways such as consumption of alcohol and hard drugs, to help them control their emotions. Research findings have shown the link between diet and some emotions/neurobehaviour. We investigated the effect of consumption of unripe plantain on fear and anxiety behaviour. Three groups of mice were fed with diet containing 100%, 50% and 0% (control) unripe plantain. Fear and anxiety behaviour was studied using the Light/Dark Transition Box and Elevated Plus Maze tests. The transitions in the light/dark chambers was not significantly (p > 0.05) different among the groups. The light chamber duration of the 100% and 50% plantain diet groups was significantly (p < 0.05) higher than control. Stretch attend postures were lower in 100% and 50% plantain diet groups compared to control. In the Elevated Plus Maze test, frequencies of open arm entry for the 100% and 50% plantain groups were significantly (p < 0.05) higher than control. The difference in open arm entries between 100% and 50% plantain diet groups was significant. The results suggest that consumption of plantain diet reduced fear and anxiety behaviour in mice. A preliminary investigation of the concentration of serotonin in the brains of the mice using High Performance Liquid Chromatography shows that serotonin is significantly (p < 0.001) higher in the 100% plantain diet group than control.

Keywords: Plantain, Serotonin, 5-Hydroxytryptophan, Fear, Anxiety
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