Modulation in Airway Smooth Muscle Reactivity and Improvement in Lung Function of Cigarette Smokers and Passive Non-smokers Following Garcinia kola treatment

Ogechukwu K. Uche* and Masagbor F. Otimize
Department of Physiology, School of Basic Medical Sciences, University of Benin, PMB 1154, Benin City. 300-001, Nigeria.
Corresponding Author: [email protected]; Tel: +2348037245912
Recieved Date: October 14, 2017; Accepted Date: October 27, 2017; Published Date: 05 November 2017
Citation: Uche OK and Otimize MF. Modulation in Airway Smooth Muscle Reactivity and Improvement in Lung Function of Cigarette Smokers and Passive Non-smokers Following Garcinia kola treatment. Trop J Nat Prod Res. 2017; 1(5):209-212. doi.org/10.26538/tjnpr/v1i5.7 https://doi.org//10.26538/tjnpr/v1i5.7
Copyright: © 2017 Uche and Otimize. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
ABSTRACT

Inhalation of tobacco smoke is a major risk factor for the development of airway hyperreactivity (AHR) in non-cigarette smokers and increase respiratory distress in smokers. Garcinia kola has been linked to smooth muscle relaxation and may ameliorate obstruction and resistance to airflow. This study examined the effect of Garcinia kola on airflow and reactivity of the airway smooth muscles (ASM) of asymptomatic regular cigarette smokers (CS) and passive non-smokers (PNS) following 10 minutes cigarette smoking and exposure to cigarette smoke. Sixty apparently healthy male undergraduates comprising cigarette smokers and non-smokers volunteered as subjects. Changes in peak expiratory flow rate (PEFR) in L/min in CS and PNS was measured with Spirometer before and after 10 minutes of smoking and/or exposure to cigarette smoke. Thereafter, half the population of CS and PNS were given G. kola (200 mg/kg body weight) and PEFR measured at intervals of 30 minutes for a maximum of 90 minutes. Peak expiratory flow rate significantly decreased (p < 0.05) following 10 minutes of smoking and exposure to smoke in both CS and PNS, however, G. kola ingestion marginally increased PEFR values significantly at 30, 60 and 90 minutes intervals. Comparatively, increase in PEFR was greater in PNS than in CS (P < 0.05) treated with G. kola and climaxed at 60 minutes. Conclusively, cigarette smoking and exposure to cigarette smoke compromise lung function with a decrease in peak expiratory flow rate. G. kola treatment significantly reversed this trend, cleared the airways, enhanced airflow and improved lung function.

Keywords: Cigarette smoke, Garcinia kola, PEFR, Airway reactivity
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