Curcumin: A Review of its Potential Role in Epigenetic Mechanism

Tanveer Ahamad1, Mohsin A. Khan1, Shahnaaz Khatoon2, Alka Kumari3, Mohammad F. Khan1*
1Department of Biochemistry, Era’s Lucknow Medical College & Hospital, Era University, Lucknow-226003, UP, India 2Department of Botany, D. N. (P.G.) College, Meerut-200005, UP, India 3Department of Botany, University of Lucknow, Lucknow-226007, UP, India
Corresponding Author: [email protected]; Tel: +91 7800737252
Recieved Date: October 24, 2017; Accepted Date: November 03, 2017; Published Date: 05 November 2017
Citation: Ahamad T, Khan MA, Khatoon S, Kumari A, Khan MF. Curcumin: A Review of its Potential Role in Epigenetic Mechanism. Trop J Nat Prod Res. 2017; 1(5):191-195. doi.org/10.26538/tjnpr/v1i5.3 https://doi.org//10.26538/tjnpr/v1i5.3
Copyright: © 2017 Ahamad et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
ABSTRACT

Curcumin, a golden-yellow powder extracted from the rhizome of the plant Curcuma longa L. (Family: Zingiberaceae) has been used as a therapeutic agent since ancient times. Curcumin is a diferuloylmethane type of compound having two ferulic acid moieties bound together through a methylene group stabilized by a hydrogen-bonded keto-enol tautomeric form. This tautomeric form is stable in acidic medium but unstable in neutral and basic pH solutions, where it is degraded to ferulic acid and feruloylmethane units. Studies on cell culture and animal models have demonstrated the potential of curcumin as an antioxidant, antibacterial, anti-inflammatory, analgesic, wound healing, antiobesity, antiatherosclerosis, anticarcinogenic and neuroprotective agent. At molecular level, it showed the reversible epigenetic regulations include changes in DNA methylation, Histone modification and alteration in microRNA (miRNA) expression without changes in DNA sequence. This review discusses the chemical nature of curcumin and its regulation of epigenetic mechanisms leading to genome rearrangements and instability at the DNA level.

Keywords: Curcumin, Curcuma longa, Epigenetic, DNA methylation, Histone modification, microRNA
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