TY - JOUR AU - To, Dao C. AU - Tran, Manh H. AU - Nguyen, Phi H. AU - Ai Nhung, Nguyen T. AU - Nguyen, Tu T. T. PY - 2023/05/01 Y2 - 2024/03/29 TI - Arginase II Inhibitory Activity of Phenolic Compounds from Caesalpinia sappan L.: http://www.doi.org/10.26538/tjnpr/v7i4.12 JF - Tropical Journal of Natural Product Research (TJNPR) JA - TJNPR VL - 7 IS - 4 SE - Articles DO - UR - https://www.tjnpr.org/index.php/home/article/view/1873 SP - 2744-2748 AB - <p>Inhibition of arginase from natural compounds has been proposed as a therapeutic approach for&nbsp;the treatment of cardiovascular diseases. Therefore, this study aims to evaluate the arginase inhibitory activity of isolated compounds. Based on bioactivity-guided fractionation, the ethyl acetate fraction was further subjected to column chromatography to obtain seven compounds (<strong>1</strong>−<strong>7</strong>). The chemical structures of the isolated compounds were determined by analyzing NMR spectral data and referring to data from the literature. The arginase II inhibitory activity of&nbsp;compounds <strong>1</strong>–<strong>7 </strong>were investigated <em>in vitro </em>using an enzyme solution prepared from the kidney of&nbsp;anesthetized C57BL/6 mice. Compounds <strong>1</strong>, <strong>2</strong>, and <strong>7 </strong>potentially inhibit arginase II activity, with IC50 values ranging from 8.1 to 14.2 μM, whereas the remaining compounds were inactive. This study is the first to assess compounds isolated from <em>C. sappan </em>heartwood with regard to their arginase inhibitory activity.&nbsp;</p> ER -