Main Article Content
There are much potential embedded in plants, ranging from air purification to ornamental and source of medicine to mankind. This study reports the biological potentials of Dennettia tripetala leaf extract and its flavonoid content for its possible usage in ameliorating. Flavonoid content of D. tripetala leaf was profiled using high performance liquid chromatography (HPLC), antioxidant and anticholinesterase properties were also studied using standard methods. The major flavonoids identified and quantified were catechin (56.17 mg/100g), kaemferol (49.80 mg/100g), quercetin (69.19 mg/100g), isorhammnetin (19.89 mg/100g) and naringin (19.55
mg/100g). There was evidence of antioxidant potential of D. tripetala leaf extract. Also, the compound, flavonoid, showed acetylcholinesterase and butrylcholinesterase inhibition of 68 and 74%, respectively. The results of the study indicated that the leaf extract of D. tripetala contains high concentrations of flavonoids and possesses antioxidant and anticholinesterases properties. It
may be used in managing oxidative stress-related diseases and dementias.
This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.
Erica AP, Monica CV, Willman AD, Oscar JP, Luis EC. Invitro antioxidant and anticholinesterase activities of columbian plants as potential neuroprotective agent. Res J Med Plant. 2018; 12:9-18.
Čolović MB, Krstić DZ, Lazarević-Pašti TD, Bondžić AM,Vasić VM. Acetylcholinesterase inhibitors: pharmacology and toxicology. Curr Neuropharmacol. 2013; 11(3):315-321.
Timothy CO and Okere CO. Effects of Dennettia tripetala (mmimi) seed intake on the IOP of normotensive emmetropic Nigeria Igbos. J Nig Optomet Assoc. 2008; 14:14-17.
Omoregie EH and Augustine IE. Major composition of the Essential oil of the fruit and comparative phytochemical studies of the fruit and leaves of Dennettia tripetala Barker F. found in North central Nigeria. Int J Pharmacogn Phytochem Res. 2015; 7(6):1262-1266.
Anyaele OO and Amusan OO. Toxicity of hexanolic extract of Dennettia tripetalaG. (Baker). Afr J Biomed Res. 2003; 6(1):49-53.
Ejechi BO and Akpomedaye DE. Activity of essential oil and phenolic extract of pepper fruit; Dennettia tripetala(G. Baker) against some food borne microorganisms. Afr J Biotech. 2005; 4(3):258-261.
Ebana RUB, Asamodu NU, Etok CA, Onyebuisi CS. Phytochemical Screening, Nutrient Analysis and Antimicrobial Activity of the leaves of Lasianthera africana and Dennettia tripetala on clinical isolates. JAdvBiol Biotech. 2016; 8(4):1-9.
Iseghohi SO. A review of the uses and medicinal properties of Dennettia tripetala (Pepper fruit). Med Sci 2015; 3:104- 111.
Omage SO, Orhue NEJ, Omage K. Evaluation of the phytochemical content, in vitro antioxidant capacity, biochemical and histological effects of Dennettia tripetala fruits in healthy rats. Food Sci Nutr. 2019; 7:65-75.
Oyemitan IA, Iwalewa EO, Akanmu MA, Asa SO, Olugbade TA. The abrasive potential of habitual consumption of the fruit of Dannettia tripetala G. Baker (Annonaceae) among the people of Ondo Township. Nig J Natl Prod Med. 2008; 10:55-62.
Anioke I, Okwuosa C, Uchendu I, Chijioke O, DozieNwakile O, Ikegwuonu I, Kalu P, Okafor M. Investigation into hypoglycaemic, antihyperlipidemic and renoprotective potentials of DT seed in a rat model of diabetes. BioMed Res Int. 2017; 2017: 6923629.
Okoh SO, Iweriegbor BC, Okoh OO, Nwodo UU, Okoh AI. Bactericidal and antioxidant properties of essential oils from the fruits of DT G Baker. BMC Compl Altern Med. 2016; 16:486-497.
Adjalian E, Sessou P, Fifa TD, Dangou BJ, Odjo T, Figueredo G. Chemical composition and bioefficacy of DT and U. angustifolium leaves essential oil against the Angoumois grain moth, Sitotroga cerealella. Int J Biosci. 2014; 5(8):161-172.
Nwosu LC, Adedire CO, Ogunwolu EO, Ashamo MO. Toxicological and histopathological effects of DT seed used as grain protectant, food and medicine. Food Qual Saf. 2017; 1(3):211-219.
A.O.A.C. Association of Official Analytical Chemistry Methods of Analysis, 2010. 202-213 p.
Nwidu LL, Elmorsy E, Thornton J, Wijamunige B, Wijesekara A, Tarbox R, Warren A, Carter WG. Anticholinesterase activity and antioxidant properties of extracts and fractions of Carpolobia lutea. Pharm Biol. 2017; 55(1):1875-1883.
Senguttuvan J, Paulsamy S, Karthika K. Phytochemical analysis and evaluation of leaf and root parts of the medicinal herb, H. radicata L. for in vitro antioxidant activities. Asian Pac J Trop Biomed. 2014; 4(1):S359-S369.
Ellman GL, Courtney KD, Andres V, Featherstone RM. A new and rapid colorimetric determination of AchE activity. BiochemPharmacol. 1961; 7:88-95.
Shen Q, Zhang B, Xu R, Wang Y, Ding X, Li P. Antioxidant activity, in vitro of selenium-contained protein from the Se-enriched Bifidobacterium animalis. Anaerobe 2010; 16(4):380-386.
Okolie PN, Falodun A, Davids O. Evaluation of the antioxidant activity of the root extract of pepper fruit and its potential for the inhibition of lipid peroxidation. Afr J Trad Compl Altern Med. 2014; 11(3):221-227.
Marrelli M, Conforti F, Araniti F, Statti GA. Effects of saponnin on lipid metabolism: a review of potential health benefits in the treatment of obesity. Molecule 2016; 21:1404-1425.
Srivastava J, Kumar S, Vankar PS. Correlation of antioxidant activity and phytochemical profile in native plants. Nutr Food Sci. 2012; 42(2):71-79.
PancheAN, Diwan AD, Chandra SR. Flavonoids: an overview. J Nutr Sci. 2016; 5:1-15.
Osuagwu GGE and Eme CF. The phytochemical composition and antimicrobial activity of Dialium guineense, Vitex doniana and Dennettia tripetala leaves. Asian J Nat Appl Sci. 2013; 2(3):69-81.
Kuete V. Health effects of alkaloids from African medicinal plants. Toxicol Survey Afr Med Plants. 2014; 1: 611-633.
Aderogba MA, Akinkunmi EO, Mabusela WT. Antioxidant and antimicrobial activities of flavonoids glycosides from DT leaf extract. Nig J Nat Prod Med. 2011; 15:1-5.
Costa LG, Garrick JM, Roque PJ, Pellacani C. Mechanism of neuroprotection by quercetin; counteracting oxidative stress and more. Oxid Med Cell Long. 2016; 1-10.
Bernatonniene J and Kopustinskiene DM. The role of catechin in cellular responses to oxidative stress. Molecules 2018; 23(4):965-973.
Clarke KA, Dew TP, Watson REB, Faarrar MD, Osman JE, Anna N, Rhodes LE, Williamson G. Green tea catechins and their metabolite in human skin before and after exposure to UV radiation. J NutrBiochem. 2016; 27:203- 0210.
Li W, Chen Z, Yan M, He P, Chen Z, Dai H. The protective role of isorhanmnettin on human brain microvascular endothelial cells from cytotoxicity induced by methylglyoxal and oxygen–glucose deprivation. J Neurochem. 2016; 136:651-659.
Chen R, Qi QL, Wang MT, Li QY. Therapeutic potential of naringin; an overview. Pharm Biol. 2016; 54(12):3203- 3210.
Khan MT, Orhan I, Enol SS. Cholinesterase inhibitoryactivities of some flavonoid derivatives and chosen xanthone and their molecular docking studies. ChemBiol Interact. 2009;181:383–389.