Cytotoxic Assessment of Xylopia aethiopica [Dun.] A. on Human Prostate and Breast Cancer Cell Lines

doi.org/10.26538/tjnpr/v4i12.18

Authors

  • Emeka E. J. Iweala Department of Biochemistry, Covenant University, PMB 1023, Ota, Ogun State, Nigeria
  • Eunice O. Bankole Department of Biochemistry, Covenant University, PMB 1023, Ota, Ogun State, Nigeria
  • Franklyn N. Iheagwam Department of Biochemistry, Covenant University, PMB 1023, Ota, Ogun State, Nigeria
  • Omoremime E. Dania Department of Biochemistry, Covenant University, PMB 1023, Ota, Ogun State, Nigeria
  • Ujowundu F. Ntite Department of Biochemistry, Federal University of Technology, Owerri, Imo State, Nigeria

Keywords:

Cancer, Medicinal plants, LNCaP, MDA-MB-231, Cell viability, Xylopia aethiopica

Abstract

Cancer is associated with the unregulated multiplication of cells in specific parts of the body. Plant-derived products are employed in the treatment and management of such malignant tumours. Prostate and breast cancers are the most common forms affecting Nigerians. Our aim is to investigate the cytotoxic effect of Xylopia aethiopica, a commonly consumed spice in Nigeria, on selected cancer cell lines. The antiproliferative activity of X. aethiopica ethanol extract of varying concentrations was assessed on MDA-MB-231, MCF-7, and LNCaP using  MTT assay. A dose-dependent antiproliferative activity was observed. The IC50 for X. aethiopica on the cell lines were ≤ 4.506 ± 0.07 µg/mL except for MCF-7 at 72 hours, where 18.86 ± 0.20 µg/mL was recorded. The findings from this study indicate the potential antiproliferative and cytotoxic property of X. aethiopica on human prostate and breast cancer cell lines. 

Author Biography

Franklyn N. Iheagwam, Department of Biochemistry, Covenant University, PMB 1023, Ota, Ogun State, Nigeria

Covenant University Public Health and Wellbeing Research Cluster (CUPHWERC), Covenant University, PMB 1023, Ota, Ogun State, Nigeria

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Published

2020-12-01

How to Cite

Iweala, E. E. J., Bankole, E. O., Iheagwam, F. N., Dania, O. E., & Ntite, U. F. (2020). Cytotoxic Assessment of Xylopia aethiopica [Dun.] A. on Human Prostate and Breast Cancer Cell Lines: doi.org/10.26538/tjnpr/v4i12.18. Tropical Journal of Natural Product Research (TJNPR), 4(12), 1143–1146. Retrieved from https://www.tjnpr.org/index.php/home/article/view/914