Medicinal Plants as Recent Complementary and Alternative Therapy for COVID-19: A Review


  • Dewa A. A. S. Laksemi Department of Parasitology, Faculty of Medicine, Udayana University, Jl PB Sudirman Denpasar 80234, Bali, Indonesia
  • Dewa M. Sukrama Department of Clinical Microbiology, Faculty of Medicine, Udayana University, Jalan PB Sudirman, Denpasar, Bali, Indonesia
  • Made Sudarmaja Department of Parasitology, Faculty of Medicine, Udayana University, Jl PB Sudirman Denpasar 80234, Bali, Indonesia
  • Putu A. A. Damayanti Department of Parasitology, Faculty of Medicine, Udayana University, Jl PB Sudirman Denpasar 80234, Bali, Indonesia
  • Kadek Swastika Department of Parasitology, Faculty of Medicine, Udayana University, Jl PB Sudirman Denpasar 80234, Bali, Indonesia
  • Ni L. P. E. Diarthini epartment of Parasitology, Faculty of Medicine, Udayana University, Jl PB Sudirman Denpasar 80234, Bali, Indonesia
  • Nyoman M. Astawa Veterinary Virology Laboratorium Faculty of Veterinary Udayana University, Jalan PB Sudirman Denpasar, 80234, Bali, Indonesia
  • Ketut Tunas Management of Health Information Department, Bali International University, Jl Seroja gg Jeruk ,Tonja, Denpasar 80234, Bali, Indonesia


Anti-viral agents, COVID-19, Medicinal plants, Mechanism of action, SARS-CoV, Molecular


The World Health Organization stated COVID-19 became a pandemic since March 11, 2020. With the absence of a vaccine and standard treatment for Covid-19 infection, individual protection including maintaining personal hygiene, consumption of food, vegetables and fruit that can increase immunity is the key to preventing COVID-19. The combination of herbs and modern therapy can contribute to lower mortality rates and a faster response in controlling outbreaks. This review is aimed to determine plants that have effect on coronavirus infection, mechanism of action, dosage, toxic effect, thus can be beneficial for strengthening health against covid-19. This research is a literature review that search articles using Google Scholar, ResearchGate, NCBI, PubMed, Web of Science and Semantic Scholar, used a combination keywords related to coronavirus or COVID-19, SARS CoV-2, herb, natural compound, mechanism of action, dosage, toxic effect, meta-analysis, review. Curcuma longa, Cinnamon, Glycyrrhizin, Kaempferia galanga, Eucalyptus essential oil, black tea, were plants that have pieces of evidence as anti-coronavirus. The molecular mechanism of these plants as anti-virals varies by inhibiting entry, blocking viral receptors, inhibiting enzymes, enhancing immune system, interfering with signal transduction, relief symptoms. Therefore, plant products used inthe right dose could be beneficial against coronavirus infection.  


Yasri S and Wiwanitkit V. Platelet count among the patients with novel coronavirus 2019 infection An observation on 46 cases. J Res Med Sci. 2020; 25(58):1.

Qifang Bi, Yongsheng Wu, Shujiang Mei. Epidemiologyandtransmission ofCOVID-19 in 391 cases and 1286 oftheirclose contacts in Shenzhen, China: A Retrospective CohortStudy. Lancet. 2020; 20(8):911-919.

Wang E and Brar K. COVID-19 in children: an epidemiology study from China J Allergy Clin Immunol Pract. 2020; 8(6):2118-2120.

Susilawati S, Falefi R, Purwoko A. Impact of COVID-19’s Pandemic on the Economy of Indonesia. Bircu J. 2020; 3(2):1147-1156.

Setiati S and Azwar MK. COVID-19 and Indonesia. Acta Medica Indonesiana. 2020; 52 (1):84-89.

Li H, Liu SM, Yu XH, Tang SL, Tang CK. Coronavirus disease 2019 (COVID-19): current status and future perspectives. Int J Antimicrob Agents. 2020; 55(5):105951.

Zimmermann P and Curtis N. Coronavirus Infections in Children Including COVID-19: An Overview of the Epidemiology, Clinical Features, Diagnosis, Treatment and Prevention Options in Children. Pediatric Infect Dis J. 2020; 39(5):355-368.

Firth A. A putative new SARS-CoV protein, 3c, encoded in an ORFoverlapping ORF3a. J General Virol. 2020; 101:1085-1089.

Li Q and Kang C. Progress in Developing Inhibitors of SARS-CoV-2 3C-Like Protease. Microorganisms. 2020;8(8):1250.

Prajapat M, Sarma P, Shekhar N, , Avti P, Sinha S, Kaur H, Kumar S, Bhattacharyya A,Kumar H, Bansal S, Medhi B. Drug targets for coronavirus: A systematic review. Indian J Pharmacol. 2020; 52(1):56-65

Shin D, Mukherjee R, Grewe D, Bojkova D, Baek K, Bhattacharya A, Schulz L, Widera M, Mehdipour AR, Tascher G, Geurink PP, Wilhelm A, Noort GJ, Ovaa H, Müller S, Knobeloch KP, Rajalingam K, Schulman BA, Cinatl J, Hummer G, Ciesek S, Dikic I. Papain-like protease

regulates SARS-CoV-2 viral spread and innate immunity. Nature. 2020; 587(7835):657-662.

Gyebi GA, Ogunro OB, Adegunloye AP, Ogunyemi OM, Afolabi SO. Potential inhibitors of coronavirus 3-chymotrypsin-like protease (3CLpro): an in silico screening of alkaloids and terpenoids from African medicinal plants. J Biomol Struct Dyn. 2020; 1-13.

Liu Y, Liang C, Xin L, Ren X, Tian L, Ju X, Li H, Wang Y, Zhao Q, Liu H, Cao W, Xie X, Zhang D, Wang Y, Jian Y. The development of oronavirus 3C-Like protease (3CLpro) inhibitors from 2010 to 2020. Eur J Med Chem. 2020; 206:112711.

Ullrich S and Nitsche C. The SARS-CoV-2 main protease as drug target. Bioorg Med Chem Lett. 2020;30(17):127377.

Jahan I and Onay A. Potentials of plant-based substance to inhabit and probable cure for the COVID-19. Turk J Biol. 2020; 44(3):228-241.

Kanyinda JNM. Coronavirus (COVID 19): A Protocol for Preventation and Treatment (Covalyse). Eur J Med Health Sci. 2020; 2(3):1-5.

Panjaitan R, Mitalia M, Partasasmita R. Indigenous knowledge of the people in Karya Usaha Hamlet (Kubu Raya, West Kalimantan, Indonesia) on the processing and diversity of plants that enhance toddler's appetite. Biodiversitas. 2016; 21(9):4284-4290.

Meng XY, Zhang HX, Mezei M, Cui M. Molecular docking: a powerful approach for structure-based drug discovery. Curr Comput Aided Drug Des. 2011; 7(2):146-157.

Basu A, Sarkar A, Maulik U. Computational approach for the design of potential spike protein binding natural compounds in SARS-CoV2. OSF Sci Rep. 2020; 10:17699.

Amin SA, Ghosh K, Gayen S, Jha T. Chemical-informatics approach to COVID-19 drug discovery: Monte Carlo based QSAR, virtual screening and molecular docking study of some in-house molecules as papain-like protease (PLpro) inhibitors. J Biomol Struct Dyn. 2020; 1-10.

Khaerunnisa S, Kurniawan H, Awaluddin R, Suhartati S, Soetjipto S. Potential Inhibitor of COVID-19 Main Protease (Mpro) From Several Medicinal Plant Compounds by Molecular Docking Study. 2020.

Fitriani U, Zulkarnain Z, Novianto F, Wijayanti E, Triyono A. Effectiveness of anemia herbal formula containing Curcuma zanthorrhiza, Elephantopus scaber and Amaranthus tricolor in iron deficiency anemia patients. Biodiversitas. 2020; 21(5):2289-2296.

Sukweenadhi J, Yunita O, Setiawan F, Kartini, Siagian MT, Danduru AP, Avanti C. Antioxidant activity screening of seven Indonesian herbal extract. Biodiversitas. 2020; 21(5):2062-2067.

Boroumand N, Samarghan S, Saeed D, Isaac H. Immunomodulatory, anti-inflammatory, and antioxidant effects of curcumin. J Herbmed Pharmacol. 2018; 7(4):211-219.

Xu Y and Liu L. Curcumin alleviates macrophage activation and lung inflammation induced by influenza virus infection through inhibiting the NF-kappaB signaling pathway. Influenza Other Respir Viruses. 2017; 11(5):457-63.

Liu Z and Ying Y. The Inhibitory Effect of Curcumin on Virus-Induced Cytokine Storm and Its Potential Use in the Associated Severe Pneumonia. Front Cell Dev Biol. 2020; 8:479.

Fuzimoto AD and Isidoro C. The antiviral and coronavirushost protein pathways inhibiting properties of herbs and natural ompounds - Additional weapons in the fight against the COVID-19 pandemic? J Trad Compl Med. 2020; 10(4):405-419.

Moghadamtousi SZ, Kadir HA, Hassandarvish P, Tajik H, Abubakar S, Zandi K. A review on antibacterial, antiviral, and antifungal activity of curcumin. Biomed Res Int. 2014:186864.

Hatamipour M, Johnston TP, Sahebkar A. One Molecule, Many Targets and Numerous Effects: The Pleiotropy of Curcumin Lies in its Chemical Structure. Curr Pharm Des. 2018; 24(19):2129-2136.

Muscogiuri G, Barrea L, Savastano S, Colao A. Nutritional recommendations for CoVID-19 quarantine. Eur J Clin Nutr. 2020; 74(6):850-851.

Bucher A and White N. Vitamin C in the Prevention and Treatment of the Common Cold. Am J Lifestyle Med. 2016;10(3):181-183.

David AVA, Arulmoli R, Parasuraman S. Overviews of Biological Importance of Quercetin: A Bioactive Flavonoid. Pharmacogn Rev. 2016; 10(20):84-89.

Polansky H and Lori G. Coronavirus disease 2019 (COVID-19): first indication of efficacy of Gene-EdenVIR/Novirin in SARS-CoV-2 infection. Int J Antimicrob Agents. 2020; 55(6):105971.

Gerszberg A, Konka KH, Kowalczyk T, Kononowicz AK. Tomato (Solanum lycopersicum L.) in the service of biotechnology. Plant Cell Tiss Organ Cult. 2014: 1-23.

Chaudhary P, Sharma A, Singh B, Nagpal AK. Bioactivities of phytochemicals present in tomato. J Food Sci Technol. 2018; 55(8):2833-2849.

Martí R, Roselló S, Cebolla-Cornejo J. Tomato as a Source of Carotenoids and Polyphenols Targeted to Cancer Prevention. Cancers (Basel). 2016; 8(6):58.

Gasmi A, Noorb S, Tippairotec T, Dadare M, Menzelf A, GeirBjorklundg.. Individual risk management strategy and potential therapeutic options for the COVID-19 pandemic. Clin Immunol. 2020; 215:108409.

Lalani S and Poh CL. Flavonoids as Antiviral Agents for Enterovirus A71 (EV-A71). Viruses. 2020; 12(2):18.

Sawikowska A. Meta-analysis of flavonoids with antiviral potential against coronavirus. Biomet Lett. 2020; 57(1):13-22.

Kumar S and Pandey AK. Chemistry and biological activities of flavonoids: an overview. Sci World J. 2013; 162750.

Somerville VS, Braakhuis AJ, Hopkins WG. Effect of Flavonoids on Upper Respiratory Tract Infections and Immune Function: A Systematic Review and MetaAnalysis. Adv Nutr. 2016; 7(3):488-497.

Jang M, Park YI, Cha YE, Park R, Namkoong S, Lee J, Park J. Tea Polyphenols EGCG and Theaflavin Inhibit the Activity of SARS-CoV-2 3CL-Protease In Vitro. EvidBased Compl Altern Med. 2020; 2020:5630838.

Casado-Díaz A, Dorado G, Quesada-Gómez JM. Influence of olive oil and its components on mesenchymal stem cell biology. World J Stem Cells. 2019; 11(12):1045-1064.

Vardhan S and Sahoo SK. In silico ADMET and molecular docking study on searching potential inhibitors from limonoids and triterpenoids for COVID-19. Comput Biol Med. 2020; 124:103936.

Budhwar S, Sethi K, Chakraborty M. A Rapid Advice Guideline for the Prevention of Novel Coronavirus Through Nutritional Intervention. Curr Nutr Rep. 2020; 9(3):119-128.

Kieliszek M and Lipinski B. Selenium supplementation in the prevention of coronavirus infections (COVID-19). Med Hypotheses. 2020; 143:109878.

de Faria Coelho-Ravagnani C, Corgosinho FC, Sanches FFZ, Prado CMM, Laviano A, Mota JF. Dietary recommendations during the COVID-19 pandemic. Nutr Rev. 2020; 067.

Alexander J. Selenium in: Handbook on the Toxicology of Metals (4ed). England: Scincedirect; 2015. 1175-1208 p.

Yang H and Jia X. Safety Evaluation of Semethylselenocysteine as Nutritional Selenium Supplement: Acute Toxicity, genotoxicity and Subchronic Toxicity. Reg Tox Pharmacol. 2014; 70(2014):720-727.

Yang Y, Islam MS, Wang J, Chen X. Traditional Chinese Medicine in the Treatment of Patients Infected with 2019-New Coronavirus (SARS-CoV-2): A Review and Perspective. Int J Biol Sci. 2020; 16:1708-1717.

Ekeanyanwu RC and Njoku OU. Acute and subacute oraltoxicity study on the flavonoid rich fraction of Monodora tenuifolia seed in albino rats. Asian Pac J Trop Biomed. 2014; 4(3):194-202.

Galati G and O'Brien PJ. Potential toxicity of flavonoids and other dietary phenolics: significance for their chemopreventive and anticancer properties. Free Radic Biol Med. 2004; 37(3):287-303.

Furushima D, Ide K, Yamada H. Effect of Tea Catechins on Influenza Infection and the Common Cold with a Focus on Epidemiological/Clinical Studies. Molecules. 2018; 23(7):1795.

Chen CN, Lin CP, Huang KK, Chen WC, Hsieh HP, Liang PH, Hsu JT. Inhibition of SARS-CoV 3C-like Protease Activity by Theaflavin-3,3'-digallate (TF3). Evid-Based Compl Altern Med. Ecam. 2005; 2(2):209-215.

Khan N and Mukhtar H. Tea and health: studies in humans. Curr Pharm Des. 2013; 19(34):6141-6147.

Sur TK, Chatterjee S, Hazra AK, Pradhan R, Chowdhury S. Acute and sub-chronic oral toxicity study of black tea in rodents. Indian J Pharmacol. 2015; 47(2):167-172.

Dey A, Gomes A, Dasgupta SC. Black Tea (Camellia sinensis) Extract Induced Prenatal and Postnatal Toxicity in Experimental Albino rats. Pharmacogn Mag. 2018; 13(4):S769-S774.

Cinatl J, Morgenstern B, Bauer G, Chandra P, Rabenau H, Doerr HW. Glycyrrhizin, an active component of liquorice roots, and replication of SARS-associated coronavirus. Lancet. 2003; 361(9374):2045-2046.

Mamedov NA and Egamberdieva D. Phytochemical Constituents and Pharmacological Effects of Licorice: A Review. Plant and Human Health. 2019; 3:1-21.

Bailly C and Vergoten G. Glycyrrhizin: An alternative drug for the treatment of COVID-19 infection and the associated respiratory syndrome? Pharmacol Ther. 2020; 214:107618.

Cecchini R and Cecchini AL. SARS-CoV-2 infection pathogenesis is related to oxidative stress as a response to aggression. Med hypotheses. 2020; 143:110102.

Susiarti S and Setyowati FM. Bahan Rempah Tradisional dari Masyarakat Dayak Kenyah di Kalimantan Timur Traditional spices of Dayak Kenyah society in East Kalimantan. Biodiversitas. 2005; 6(4):285-287.

Prasanth DSNBK, Murahari M, Chandramohan V, Panda SP, Atmakuri LR, Guntupalli C. In silico identification of potential inhibitors from Cinnamon against main protease and spike glycoprotein of SARS CoV-2. J Biomol Struct Dyn. 2020; 1-15.

Kawatra P and Rajagopalan R. Cinnamon: Mystic powers of a minute ingredient. Pharmacogn Res. 2015; 7(1):S1-S6.

Baukhatem M. Effective Antiviral Activity of Essential Oils and their Characteristic Terpenes against Coronaviruses: An Update. J Pharmacol Clin Toxicol. 2020; 8(1):1138.

Wu CY, Jan JT, Ma SH. Small molecules targeting severe acute respiratory syndrome human coronavirus. Proc Natl Acad Sci. 2004; 101(27):10012-10017.

Wińska K, Mączka W, Łyczko J, Grabarczyk M, Czubaszek A, Szumny A. Essential Oils as Antimicrobial Agents-Myth or Real Alternative? Molecules. 2019; 24(11):2130.

Lin Ang, Eunhye Song, Hye Won Lee, and Myeong SooLee. Herbal Medicine for the Treatment of Coronavirus Disease 2019 (COVID-19): A Systematic Review and Meta-Analysis of Randomized Controlled Trials. J Clin Med. 2019; 9(1583):1-20.

Xiong X, Wang P, Su K, Cho WC, Xing Y. Chinese herbal medicine for coronavirus disease A systematic review and meta-analysis. Pharmacol Res. 2019; 160:105056.

Sharma AD and Kaur I. Jensenone form Eucalyptus Essential Oils as Potential Inhibitor of Covid-19 Coronavirus Infection. Res Rev Biotech Biosci. 2020;7(1):59-66.

Silva JKRD, Figueiredo PLB, Byler KG, Setzer WN. Essential Oils as Antiviral Agents. Potential of Essential Oils to Treat SARS-CoV-2 Infection: An InSilico Investigation. Int J Mol Sci. 2020; 21(10):3426.

Elufioye TO and Habtemariam S. Drug Development for the Management of Coronaviruses: Insights from Natural Antiviral Agents. Trop J Nat Prod Res. 2020; 4(9):490-511.

Silva Andrade B, Ghosh P, Barh D. Computational screening for potential drug candidates against the SARSCoV-2 main protease. es. 2020; 9:514.

Bermano G, Méplan C, Mercer DK, Hesketh JE. Selenium and viral infection: are there lessons for COVID-19? Br J Nutr. 2020; 1-10.

Gupta SC, Patchva S, Aggarwal BB. Therapeutic roles of curcumin: lessons learned from clinical trials. AAPS J.2013; 15(1):195-218

Bethesda. Green Tea in Liver Tox: Clinical and Research Information on Drug-Induced Liver Injury. [Online]. 2012[Updated 2018 Mar 12]. Available from:




How to Cite

Laksemi, D. A. A. S., Sukrama, D. M., Sudarmaja, M., Damayanti, P. A. A., Swastika, K., Diarthini, N. L. P. E., … Tunas, K. (2020). Medicinal Plants as Recent Complementary and Alternative Therapy for COVID-19: A Review: Tropical Journal of Natural Product Research (TJNPR), 4(12), 1025–1032. Retrieved from

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