Antioxidant Activity of Facial Wash, Moisturizer, and Serum Containing Andrographis paniculata Extract, Syzygium aromaticum Oil, and Pogostemon cablin Oil


  • Oktavia R. Adianingsih Department of Pharmacy, Faculty of Medicine, Universitas Brawijaya, Malang 65145, Indonesia
  • Valentina Yurina Department of Pharmacy, Faculty of Medicine, Universitas Brawijaya, Malang 65145, Indonesia
  • Oktavia E. Puspita Department of Pharmacy, Faculty of Medicine, Universitas Brawijaya, Malang 65145, Indonesia
  • Dhelya Widasmara Department of Dermatology and Venereology, Faculty of Medicine, Universitas Brawijaya, Malang 65145, Indonesia
  • Didik Hariyono Department of Agronomy, Faculty of Agriculture, Universitas Brawijaya, Malang 65145, Indonesia
  • Jessica A. W. Dhinata Department of Pharmacy, Faculty of Medicine, Universitas Brawijaya, Malang 65145, Indonesia



facial wash, moisturizer, serum, anti-aging, antioxidant, 2,2-diphenyl-1-picrylhydrazyl


Oxidative stress is closely associated with the aging process, prompting an investigation into the therapeutic potential of Andrographis paniculata extract, Syzygium aromaticum oil, and Pogostemon cablin oil, herbs known for their widespread medicinal use. This study aimed to assess the antioxidant properties of skincare products, including facial wash, moisturizer, and serum formulated with these oild and extract. Utilizing the DPPH assay to evaluate antioxidant activity, we found that all products displayed antioxidant activity, with the serum showing the greatest efficacy (IC50 value of 2792.17 μg/mL) compared to the moisturizer (IC25 value of 2541.73 μg/mL) and facial wash (IC25 value of 2752.01 μg/mL). Notably, all products (with active ingredients) significantly enhanced radical scavenging activity over the product bases (products without active ingredients) at 5000 μg/mL, with percentage improvement as follows: serum 53.48 ± 1.50%, moisturizer 39.5 ± 2.18%, and facial wash 7.23 ± 2.20%. These findings suggest that facial wash, moisturizer, and serum containing the combination of Andrographis paniculata extract, Syzygium aromaticum oil, and Pogostemon cablin oil have the potential to become effective anti-aging treatments in the cosmetic market due to their antioxidant properties. Further studies are needed to assess their mechanism of action as anti-aging cosmetics.


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How to Cite

Adianingsih, O. R., Yurina, V., Puspita, O. E., Widasmara, D., Hariyono, D., & Dhinata, J. A. W. (2024). Antioxidant Activity of Facial Wash, Moisturizer, and Serum Containing Andrographis paniculata Extract, Syzygium aromaticum Oil, and Pogostemon cablin Oil. Tropical Journal of Natural Product Research (TJNPR), 8(6), 7575–7579.