Glucogallin and Conjugated Linoleic Acids Isolated from Ricinodendron heudelotii (Bail.) Seeds

Authors

  • Tamuno-Boma Odinga Department of Biochemistry, Faculty of Science, Rivers State University, Nigeria.
  • Peron B. Leutcha Department of Chemistry, Faculty of Science, University of Maroua, Cameroon.
  • Gloria I. Ndukwe Department of Chemistry, Faculty of Science, Rivers State University, Nigeria.
  • Sammer Yousuf HEJ, International Center for Chemical and Biological Science, University of Karachi, Pakistan.
  • Mohammad I. Choudhary HEJ, International Center for Chemical and Biological Science, University of Karachi, Pakistan.
  • Oghenetekevwe Efekemo Department of Chemical Sciences, Biochemistry Programme, Faculty of Science, Edwin Clark University, Kiagbodo, Delta State, Nigeria.
  • Miebaka B. Otobo Department of Medical Biochemistry, Faculty of Basic Medical Sciences, College of Health Sciences, University of Port Harcourt, Nigeria.
  • Sarah K. Enebeli Department of Pharmacology and Therapeutics, Faculty of Basic Clinical Sciences, College of Medical Sciences, ‘’Rivers State University, Port Harcourt, Nigeria
  • Barizoge C. Lemii Department of Pharmacology and Therapeutics, Faculty of Basic Clinical Sciences, College of Medical Sciences, ‘’Rivers State University, Port Harcourt, Nigeria
  • Ucheawaji F. Edward Department of Pharmacology and Therapeutics, Faculty of Basic Clinical Sciences, College of Medical Sciences, ‘’Rivers State University, Port Harcourt, Nigeria

DOI:

https://doi.org/10.26538/tjnpr/v8i6.31

Keywords:

Anti-diabetic activity, Anti-inflammation activity, Gallic acid, Glucogallin, Linolenic acid, Ricinodendron heudelotii, Euphorbiceae

Abstract

In a bid to explore and enhance the use of natural products for medicinal purposes, this study analyzed the crude extract of Ricinodendron heudelotii seeds and isolated four biologically active compounds from ethyl acetate fraction of R. heudelotii seeds extract. The study utilized GC-MS in the analysis of the crude extract. Various spectroscopic and spectrometric methods in addition to reported data were employed in characterizing isolates. Twenty-two compounds were detected in the crude extract via GC-MS. Palmitic acid had the highest abundance of 23.9%, followed by α-linolenic acid (14.72%). The ethyl acetate fraction by means of chromatographic techniques yielded four compounds namely glucogallin (1), (6Z,9Z,11Z)-6,9,11-octadecatrienoic acid (2), (6Z,9E,11E)-6,9,11-octadecatrienoic acid (3) and (6Z,9Z,13Z)-6,9,13-octadecatrienoic acid (4). All four isolated compounds have biological and pharmaceutical properties including anti-inflammatory and anti-diabetic. This study, therefore, proposes linolenic acid and gallic acid derivatives as chemophenetic markers of R. heudelotii and suggests the medicinal use of R. heudelotii seeds for anti-inflammatory and anti-diabetic disorders.

Author Biographies

Tamuno-Boma Odinga, Department of Biochemistry, Faculty of Science, Rivers State University, Nigeria.

HEJ, International Center for Chemical and Biological Science, University of Karachi, Pakistan.

Peron B. Leutcha, Department of Chemistry, Faculty of Science, University of Maroua, Cameroon.

HEJ, International Center for Chemical and Biological Science, University of Karachi, Pakistan.

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Published

2024-06-29

How to Cite

Odinga, T.-B., Leutcha, P. B., Ndukwe, G. I., Yousuf, S., Choudhary, M. I., Efekemo, O., … Edward, U. F. (2024). Glucogallin and Conjugated Linoleic Acids Isolated from Ricinodendron heudelotii (Bail.) Seeds. Tropical Journal of Natural Product Research (TJNPR), 8(6), 7530–7534. https://doi.org/10.26538/tjnpr/v8i6.31