Inhibitory Effects of Jasminum subtriplinerve Extracts on Nitric Oxide Production and Antioxidant Activity: Influence of Plant Parts and Cultivation Locations in Central Vietnam
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Jasminum subtriplinerve, a Southeast Asia medicinal plant, is traditionally used in Vietnam for its anti-inflammatory, pain-relieving, and antioxidant activity. This study investigates the potential of J. subtriplinerve extracts from the leaf and stem, green fruit, and ripe fruit (obtained from different biological cultivation locations) to inhibit nitric oxide (NO) production and scavenge DPPH radicals. Results reveal significant variations in IC50 values among different plant parts and cultivation locations. The results show that the leaf and stem extracts demonstrated the most potent inhibition of NO production, with the lowest IC50 value observed in Dong Giang (72.46 μg/mL). Conversely, the green and ripe fruit extracts showed weak inhibitory effects, with IC50 values exceeding 90 μg/mL in most cases. Furthermore, analysis of scavenging activity against free radicals using DPPH assay showed similar trends, with the leaf and stem extract exhibiting more potent inhibitory activities than fruit extracts. SC50 values for LS extracts ranged from 36.83 to 50.95 μg/mL. In contrast, GF and RF extracts exhibited weak antioxidant activity, SC50 values exceeding 60 μg/mL, and, in some cases, negligible biological activity (>100 μg/mL). These findings underscore the importance of considering both the plant part and the cultivation location when evaluating the efficacy of J. subtriplinerve extracts in modulating NO production and antioxidant activity.
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Reshma D, Tharakan ST, Anitha CT. Phytochemical and pharmacological properties of five different species of Jasminum. Plant Archives. 2021; 21(2): 126-36. : doi: 10.51470/PLANTARCHIVES.2021.v21.no2.022.
El-Hawary SS, El-Hefnawy HM, Osman SM, El-Raey MA, Mokhtar FA, Ibrahim HA. Antioxidant, anti-inflammatory and cytotoxic activities of Jasminum multiflorum (Burm. F.) Andrews leaves towards MCF-7 breast cancer and HCT 116 colorectal cell lines and identification of bioactive metabolites. Anti-Cancer Agents Med. Chem. 2021; 21(18): 2572-82. doi: 10.2174/1871520621666210901103440.
El-Shiekh RA, Hussein D, Atta AH, Mounier SM, Mousa MR, Abdel-Sattar E. Anti-inflammatory activity of Jasminum grandiflorum L. subsp. floribundum (Oleaceae) in inflammatory bowel disease and arthritis models. Biomed. Pharmacother. 2021;140:111770.
Polat DÇ, İlgün S, Karatoprak GŞ, Akkol EK, Capasso RJM. Phytochemical Profiles, Antioxidant, Cytotoxic, and Anti-Inflammatory Activities of Traditional Medicinal Plants: Centaurea pichleri subsp. pichleri, Conyza canadensis, and Jasminum fruticans. Molecules. 2022; 27(23): 8249. doi: 10.3390/molecules27238249.
Bharathi PR, Sripathi SK. Towards the development of natural product based anti-inflammatory therapy: Computational investigations to identify selective inhibitors. 2022; Int. J. Health Sci, 6(S6), 1541–1555.
Quang BH, Chinh VT. Plant species used as medicine in the Jasmine family (OLEACEAE Hoffmanns. & Link) in Vietnam. The 4th National Scientific Conference on Ecology and Biological Resources. 2014.
Lai XB, Ngo KL, Manh TD, Van Dinh T, Thu XN, Nguyen DK, Dang NN. Inhibition properties of Vang tea-water extract for carbon steel corrosion in acidic environments. J. Taiwan Inst. Chem. Eng. 2023;149:104941.
Bich DH, Chung DQ, Chuong BX, Dong NT, Dam DT, Hien PV, Lo VN, Mai PD, Man PK, Nhu DT. Medicinal 8.plants and medicinal animals in Vietnam. Science and Technics Publishing House. 2004. 1.
Loi DT. Vietnamese medicinal plants and herbs. Medical Publishing House. 2004.
Chi VV. The Vietnamese Dictionary of Medicinal Plants. Medical Publishing House, Ho Chi Minh City, Viet Nam. 1997.
Bharathi PR, Sripathi SK. Towards the development of natural product-based anti-inflammatory therapy. Int. J. Health Sci, 2022; 1541-55.
Tuoi DTH, Quang NT, Tinh QV, Oanh TKN, Tuyen L, Thanh N. Study on the analgesic, anti-inflammatory and hypouricemic effects of 50% ethanolic extract from Jasminum subtriplinerve Blume. Med Pharm Res. 2022; 6(2): 43-8. doi: 10.32895/UMP.MPR.6.2.6.
Ngan DH, Hoai HT, Huong le M, Hansen PE, Vang O. Bioactivities and chemical constituents of a Vietnamese medicinal plant Che Vang, Jasminum subtriplinerve Blume (Oleaceae). Nat. Prod. Res. 2008; 22(11): 942-9.
Huong NTD, Son PH, Huong BDT, Hoai HTC, Mai NTT. Bioactivities and chemical constituents of a vietnamese medicinal plant Vang se Jasminum subtriplinerve Blume. Science and Technology Development Journal. 2012; 15(3), 37-44.
Dai DN, Thang TD, Ogunwande IA, Lawal OA. Study on essential oils from the leaves of two Vietnamese plants: Jasminum subtriplinerve CL Blume and Vitex quinata (Lour) FN Williams. Nat. Prod. Res. 2016; 30(7): 860-4. doi: 10.1080/14786419.2015.1071364.
Huong NTH, Cu NKQ, Quy TV, Zidorn C, Ganzera M, Stuppner H. A new phenylpropanoid glycoside from Jasminum subtriplinerve Blume. J. Asian Nat. Prod. Res. 2008; 10(11): 1035-8.
Bao NC. Chemical constituents of che vang (Jasminum subtriplinerve cl Blume) from Quang Tri province. Hue University Journal of Science: Natural Science. 2016; 116(2).
Philip R, Krishnasamy K, Abraham E. Evaluation of anti-inflammatory activity of Jasminum sessiliflorum extracts. Int J Res Pharm Biomed Sci. 2019; 10: 2515-8.
Chaudhary, P., Janmeda, P., Docea, A. O., Yeskaliyeva, B., Abdull Razis, A. F., Modu, B., ... & Sharifi-Rad, J. Oxidative stress, free radicals and antioxidants: Potential crosstalk in the pathophysiology of human diseases. Front Chem. 2023; 11, 1158198. doi.org/10.3389/fchem.2023.1158198
Mintz J, Vedenko A, Rosete O, Shah K, Goldstein G, Hare JM & Arora H. Current advances of nitric oxide in cancer and anticancer therapeutics. Vaccines. 2021; 9(2), 94. doi.org/10.3390/vaccines9020094
Pizzino G, Irrera N, Cucinotta M, Pallio G, Mannino F, Arcoraci V, Squadrito F, Altavilla D, Bitto A. Oxidative Stress: Harms and Benefits for Human Health. Oxid Med Cell Longev. 2017; 8416763. doi: 10.1155/2017/8416763.
Balkrishna A, Rohela A, Kumar A, Kumar A, Arya V, Thakur P, Oleksak P, Krejcar O, Verma R, Kumar D. Mechanistic insight into antimicrobial and antioxidant potential of Jasminum species: A herbal approach for disease management. Plants. 2021; 10(6): 1089. doi: 10.3390/plants10061089
Gogoi R, Loying R, Sarma N, Munda S, Kumar Pandey S, Lal M. A comparative study on antioxidant, anti-inflammatory, genotoxicity, antimicrobial activities and chemical composition of fruit and leaf essential oils of Litsea cubeba Pers from North-east India. Ind Crops Prod. 2018; 125: 131-9. doi: 10.1016/j.indcrop.2018.08.052.
Boo HO, Park JH, Woo SH, Park HY. Antimicrobial effect, antioxidant and tyrosinase inhibitory activity of the extract from different parts of Phytolacca americana L. Korean J. Crop Sci.2015; 60(3): 366-73. doi: 10.7740/kjcs.2015.60.3.366
Liu W, Liu J, Yin D, Zhao X. Influence of ecological factors on the production of active substances in the anti-cancer plant Sinopodophyllum hexandrum (Royle) TS Ying. J PLoS one. 2015; 10(4): e0122981. doi: 10.1371/journal.pone.0122981.
Zhang M, Jiang D, Yang M, Ma T, Ding F, Hao M, Yuan C, Chunghong Z, Xiaobo Z, Li M. Influence of the environment on the distribution and quality of Gentiana dahurica Fisch. Front Plant Sci. 2021; 12, 706822.
Zeng Y, Guo, LP, Yang, G, Chen, BD, Wang JY, & Huang LQ. Effect of environmental ecological factors on saponins of medicinal plant. Chin. J. Exp. Tradit. Med. Form. 2012; 17, 314-318.
Tien NH, Nhi HTQ, Vuong PT, Hoai NT, Linh NKT,. Development of an HPLC procedure for quantitative determination of verbascoside in Jasminum subtriplinerve (Blume.). Pharmaceutical Journal. 2018; 501: 57-60.
The Plant List. Jasminum subtriplinerve Blume is a synonym of Jasminum nervosum Lour.: The Plant List; 2013. Version 1.1: Available from: http://www.theplantlist.org/tpl1.1/record/kew-351696.
Ngo DH, Qian ZJ, Vo TS, Ryu B, Ngo DN, & Kim S.K. Antioxidant activity of gallate-chitooligosaccharides in mouse macrophage RAW264. 7 cells. Carbohydr. Polym. 2011; 84(4), 1282-1288.
Trinh MD, Dinh MH, Ngo DH, Tran DK, Tran QT, Vo TS, Ngo DN. Protection of 4-hydroxybenzyl-chitooligomers against inflammatory responses in Chang liver cells. Int J Biol Macromol. 2014; 66: 1-6. doi: 10.1016/j.ijbiomac.2014.01.064
Abramovič H, Grobin B, Poklar Ulrih N, Cigić B. Relevance and Standardization of In Vitro Antioxidant Assays: ABTS, DPPH, and Folin–Ciocalteu. J. Chem. 2018; 2018: 1-9. doi: 10.1155/2018/4608405.
Telascrea M, de Araújo CC, Marques MO, Facanali R, de Moraes PL, Cavalheiro A. Essential oil from leaves of Cryptocarya mandioccana Meisner (Lauraceae): Composition and intraspecific chemical variability. Biochem. Syst. Ecol. 2007; 35(4): 222-32. doi: 10.1016/j.bse.2006.09.015.
Rahimmalek M, Tabatabaei BES, Etemadi N, Goli SAH, Arzani A, Zeinali H. Essential oil variation among and within six Achillea species transferred from different ecological regions in Iran to the field conditions. Ind Crops Prod. 2009; 29(2-3): 348-55. doi: 10.1016/j.indcrop.2008.07.001.
Marrassini C, Peralta I, & Anesini C. Comparative study of the polyphenol content-related anti-inflammatory and antioxidant activities of two Urera aurantiaca specimens from different geographical areas. Chinese medicine. 2018; 13, 1-12.
Chrysargyris A, Mikallou M, Petropoulos S, Tzortzakis N. Profiling of essential oils components and polyphenols for their antioxidant activity of medicinal and aromatic plants grown in different environmental conditions. Agronomy. 2020; 10(5): 727. doi: 10.3390/agronomy10050727.
Sengar N, Joshi A, Prasad SK, Hemalatha S. Anti-inflammatory, analgesic and antipyretic activities of standardised root extract of Jasminum sambac. J Ethnopharmacol. 2015; 160: 140-8. doi: 10.1016/j.jep.2014.11.039.
Tadiwos Y, Nedi T, Engidawork E. Analgesic and anti-inflammatory activities of 80% methanol root extract of Jasminum abyssinicum Hochst. ex. Dc. (Oleaceae) in mice. J Ethnopharmacol. 2017; 202: 281-9. doi: 10.1016/j.jep.2017.02.036
Chaturvedi AP, Tripathi YB. Methanolic extract of leaves of Jasminum grandiflorum Linn modulates oxidative stress and inflammatory mediators. Inflammopharmacology. 2011; 19: 273-81.
Yan WX, Zhang JH, Zhang Y, Meng DL, Yan D. Anti-inflammatory activity studies on the stems and roots of Jasminum lanceolarium Roxb. J Ethnopharmacol. 2015; 171: 335-41. doi: 10.1016/j.jep.2015.05.044.
El-Hawary SS, El-Hefnawy HM, Osman SM, El-Raey MA, Mokhtar Ali FA. Phenolic profiling of different Jasminum species cultivated in Egypt and their antioxidant activity. Nat Prod Res. 2021; 35(22): 4663-8. doi: 10.1080/14786419.2019.1700508.
Kumaresan M, Kannan M, Sankari A, Chandrasekhar C, Vasanthi D. Phytochemical screening and antioxidant activity of Jasminum multiflorum (pink Kakada) leaves and flowers. J Pharmacogn Phytochem. 2019; 8(3): 1168-73.
Huo, L, Lu, R, Li, P, Liao, Y, Chen, R, Deng, C, Li, Y. Antioxidant activity, total phenolic, and total flavonoid of extracts from stems of Jasminum nervosum Lour. Grasas y aceites. 2011; 62(2), 149-154.
Okolie NP, Falodun A, Oluseyi D. Evaluation of the antioxidant activity of root extract of pepper fruit (Dennetia tripetala), and its potential for the inhibition of Lipid peroxidation. Afr J. Trad Compl and Altern Med. 2014; 11(3):221-227. doi: 10.4314/ajtcam. v11i3.31.
Thanh P, Yen VT, Duc TM, Dien D, Que HTH, Thanh TN. Anti-inflammatory and Antioxidant Activities of Root Extract of Morinda officinalis from Quang Binh Province, Vietnam. Trop. J. Nat. Prod. Res. 2023;7(9):3932-5. doi: 10.26538/tjnpr/v7i9.13.