Radiofrequency (4g) Exposure Effects on Dentate Gyrus structure and Function in Wistar rats: Pre- vs. Postnatal Impact

Authors

  • Fabiyi Oluseyi Sunday Department of Anatomy, School of Basic Medical Sciences, Benjamin Carson Snr College of Health and Medical Sciences, Babcock University, Ilisan-Remo, Ogun State, Nigeria
  • Olubunmi Esther Ogunbiyi Department of Anatomy, School of Basic Medical Sciences, Benjamin Carson Snr College of Health and Medical Sciences, Babcock University, Ilisan-Remo, Ogun State, Nigeria
  • Owolabi Joshua Oladele Department of Anatomy, School of Basic Medical Sciences, Benjamin Carson Snr College of Health and Medical Sciences, Babcock University, Ilisan-Remo, Ogun State, Nigeria
  • Kolawole Oluwaseyi Department of Anatomy, School of Basic Medical Sciences, Benjamin Carson Snr College of Health and Medical Sciences, Babcock University, Ilisan-Remo, Ogun State, Nigeria
  • Olanrewaju John Afees Department of Anatomy, School of Basic Medical Sciences, Benjamin Carson Snr College of Health and Medical Sciences, Babcock University, Ilisan-Remo, Ogun State, Nigeria
  • Olanrewaju Barbra Zainab Department of Anatomy, School of Basic Medical Sciences, Benjamin Carson Snr College of Health and Medical Sciences, Babcock University, Ilisan-Remo, Ogun State, Nigeria
  • Adetunji Opeyemi Adebola Department of Anatomy, School of Basic Medical Sciences, Benjamin Carson Snr College of Health and Medical Sciences, Babcock University, Ilisan-Remo, Ogun State, Nigeria
  • Ogunsanya Sanmi Tunde Department of Anatomy, School of Basic Medical Sciences, Benjamin Carson Snr College of Health and Medical Sciences, Babcock University, Ilisan-Remo, Ogun State, Nigeria
  • Adeniji Kehinde Oluwaseyi Department of Anatomy, School of Basic Medical Sciences, Benjamin Carson Snr College of Health and Medical Sciences, Babcock University, Ilisan-Remo, Ogun State, Nigeria
  • Olanyinka Olugbega olawole Department of Anatomy, School of Basic Medical Sciences, Benjamin Carson Snr College of Health and Medical Sciences, Babcock University, Ilisan-Remo, Ogun State, Nigeria
  • Oyewumi Samson Oluwole Department of Physiology, School of Basic Medical Sciences, Benjamin Carson Snr College of Health and Medical Sciences, Babcock University, Ilisan-Remo, Ogun State, Nigeria
  • Onyema Kelechi Roselyn Department of Anatomy, School of Basic Medical Sciences, Benjamin Carson Snr College of Health and Medical Sciences, Babcock University, Ilisan-Remo, Ogun State, Nigeria
  • Ajiboye Oluwapelumi Department of Basic Sciences, School of Science and Technology, Babcock University, Ilishan Remo, Ogun State, Nigeria.
  • David Beaulah Mkpuruoma Department of Anatomy, School of Basic Medical Sciences, Benjamin Carson Snr College of Health and Medical Sciences, Babcock University, Ilisan-Remo, Ogun State, Nigeria

DOI:

https://doi.org/10.26538/tjnpr/v8i6.7%20

Keywords:

radiation, dentate gyrus, neurogenesis, Radiofrequency

Abstract

The study investigates 4G radiofrequency-modulated electromagnetic fields (RF-EMF) impact on prenatal/postnatal neurogenesis in Wistar rats' dentate gyrus, crucial for memory and learning, amid concerns over gadget-related RF exposure. Thirty-five pregnant female Wistar rats were randomly assigned into seven groups (n=5/group): A-G. Group A was the control, while the rest were exposed to varying durations of electromagnetic fields. At birth, four pups/group were euthanized; the rest were exposed until postnatal day 35. Neurobehavioral tests (Y-maze, Open field), histological (Haematoxylin & Eosin), Immunohistochemical (Ionized calcium-binding adaptor molecule 1, caspase-3 assays), neurotransmitters (glutamate, serotonin, dopamine, Gamma Amino Butyric Acid), and Enzymes (Cytochrome-c-oxidase assay) were evaluated in dentate gyrus pre and postnatally.  Radiofrequency radiation had mixed effects on dentate gyrus functions, impacting behavior both positively and negatively. Neurotransmitter and enzyme assays indicated mild negative effects, while histological and immunohistochemical analyses revealed aberrations in both pre and postnatal exposure groups. Altogether, 4G RF induced mild alterations in the overall structure of the dentate gyrus which could interfere with neurogenesis and neural plasticity.

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Published

2024-06-29

How to Cite

Sunday, F. O., Ogunbiyi, O. E., Oladele, O. J., Oluwaseyi, K., Afees, O. J., Zainab, O. B., … Mkpuruoma, D. B. (2024). Radiofrequency (4g) Exposure Effects on Dentate Gyrus structure and Function in Wistar rats: Pre- vs. Postnatal Impact. Tropical Journal of Natural Product Research (TJNPR), 8(6), 7382–7387. https://doi.org/10.26538/tjnpr/v8i6.7