Cytotoxic Activity of Xanthones from the Stem Bark of <i>Cratoxylum sumatranum</i>
http://www.doi.org/10.26538/tjnpr/v7i9.9
Keywords:
cancer, T47D cells, macluraxanthone, gerontoxanthone I, xanthone, Cratoxylum sumatranumAbstract
Two xanthones, gerontoxanthone I and macluraxanthone, were isolated from the stem bark of Cratoxylum sumatranum. Their structures were determined based on UV, HRESI-MS, 1D, and 2D NMR spectral data. Compounds 1 and 2 showed high activity against T47D cells with an IC50 of 1.10 and 1.60 μg/mL.
References
Ismail S, Aminyoto M. Aphrodisiac activity of ethanol extract of Cratoxylum sumatranum (Jack) Blume stems on isolated rat corpus cavernosum. J. Trop. Pharm. Chem, 2018; 4(3):74-76.
Tantapakul C, Maneerat W., Sripisut T, Ritthiwigrom T, Andersen RJ, Cheng P, Cheenpracha S, Raksat A, Laphookhieo S, New benzophenones and xanthones from Cratoxylum sumatranum ssp. neriifolium and their antibacterial and antioxidant activities, J. Agric. Food Chem, 2016; 64(46):8755–8762
Seo EK, Kim NC, Wani MC, Wall ME, Navarro HA, Burgess JP, Kawanishi K, Kardono LBS, Riswan S, Rose WC, Fairchild CR, Farnsworth NR, Kinghorn AD, Cytotoxic prenylated xanthones and the unusual compounds anthraquinobenzophenones from Cratoxylum sumatranum,
J. Nat. Prod, 2002; 65(3):299–305.
Laphookhieo S, Syers JK, Kiattansakul R, Chantrapromma K, Cytotoxic and antimalarial prenylated xanthones from Cratoxylum cochinchinense, Chem. Pharm. Bull, 2006; 54(5):745–747
Li ZP, Lee HH, Uddin Z, Song YH, Park KH, Caged xanthones displaying protein tyrosine phosphatase 1B (PTP1B) inhibition from Cratoxylum cochinchinense, Bioorganic Chem, 2018; 78:39–45.
Nonpunya A, Sethabouppha B, Rufini S, Weerapreeyakul N. Cratoxylum formosum ssp. pruniflorum activates the TRAIL death receptor complex and inhibits topoisomerase, South African J. Botany, 2018; 114:150-162.
Tanjung M, Juliawaty LD, Hakim EH, Syah YM. Flavonoid and stilbene derivatives from the Macaranga trichocarpa. Fitoterapia, 2018; 126: 74-77.
Saputri RD, Tjahjandarie TS, Tanjung M. Two novel coumarins bearing acetophenone derivative from the leaves of Melicope quercifolia. Nat. Prod. Res, 2021; 35(8):1256- 1261.
Nurlelasari Rahmayanti I, Salam S, Safari A, Harneti D, Maharani R, Hidayat AT, Tanjung M, Retnowati R, Shiono Y, Supratman, U. A new havanensin-type limonoid from Chisocheton macrophyllus. Appl. Biol. Chem, 2021; 64: 35.
Tjahjandarie TS, Tanjung M, Saputri RD, Aldin MF, Aldin MF, Susanti RA, Wibawa RS, Halizah IN. Cytotoxicity evaluation of two new chalcones from the leaves of Flemingia macrophylla (Willd.) Merr. Phytochem. Lett, 2021; 44: 78-81.
Mardhiyyah S, Zakiyah M, Renata ED, Tjahjandarie TS, Supratman U, Retnowati R, Saputri RD, Tanjung M. Isolation of lignans from the stem bark of Willughbeia coricea and their cytotoxic activity, Trop. J. Nat. Prod. Res, 2023; 7(2):2394-2396.
Tanjung M, Tjahjandarie TS , Saputri RD, Kurnia BD, Rachman MF, Syah YM. Calotetrapterins A-C, three new pyranoxanthones and their cytotoxicity from the stem bark of Calophyllum tetrapterum. Nat. Prod. Res, 2021; 35(3):407-412.
Tanjung M, Nurmalasari I, Wilujeng AK, Saputri RD, Rachmadiarti F, Tjahjandarie TS. Acronyculatin P, a new isoprenylated acetophenone from the stem bark of Acronychia pedunculata. Nat. Prod. Sci, 2018; 24(4):284- 287.
Tanjung M, Tjahjandarie TS, Saputri RD, Aldin MF, Purnobasuki H. Two new pyranoxanthones from the stem bark of Calophyllum pseudomole P.F. Steven. Nat. Prod. Res, 2022; 36(3):822-827.
Tjahjandarie TS, Tanjung M, Rachmania DF, Rhidoma CI, Saputri RD. Calodioscurins A and B, two new isoprenylated xanthones from the stem bark of Calophyllum dioscurii P.F. Steven. Nat. Prod. Res, 2021; 35(7):1153-1158.
Chang C-H, Lin C-C, Kawata Y, Hattori M, Namba T. Prenylated xanthones from Cudrania chochinchinensis. Phytochem, 1989. 6(10):2823–2826
Monache FD, Botta B, Nicoletti M, Coêlho JSB, Lyra, FDA. 1981. Three new xanthones and macluraxanthone from Rheedia benthamiana Pl. Triana (Guttiferae). J. Chem. Soc, Perkin Transactions 1:484–488.
Tjahjandarie TS, Tanjung M, Saputri RD, Rahayu DO, Gunawan ANI, Aldin MF, Aldin MF. Two new 2- arylbenzofurans from Sesbania grandiflora L. and their cytotoxicity towards cancer cells. Nat. Prod. Res, 2021; 35(24):5637-5642.
Published
How to Cite
Issue
Section
License
Copyright (c) 2023 Tropical Journal of Natural Product Research (TJNPR)
This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.
