Formulation, Physical Quality, and Microbial Contamination Tests of Anti-Acne Cream from Longan (Euphoria longan [Lour. Steud.]) Seed Extract
http://www.doi.org/10.26538/tjnpr/v7i7.5
Keywords:
Formulation, Anti-acne cream, Euphoria LonganAbstract
Acne is commonly associated with Propionibacterium acnes, a bacterium that can be treated by giving out anti-acne medications. These medications' anti-acne effects are derived from natural plant chemicals, like those in the seeds of longan (Euphoria longan [Lour. Steud.]) fruits. Longan seed extract needs to be made into a cream dosage form before it can be utilized as an anti-acne
treatment. Therefore, the present study was aimed at formulating longan seed extract cream with an anti-acne activity that meets the stability requirements of physical quality and microbial contamination tests. The longan seeds were extracted. Cream preparations with vanishing cream bases were formulated and evaluated for their anti-acne activity, physical stability, and microbial
contamination. The antibacterial effect was tested, while minimum inhibitory and minimum bactericidal concentration analyses were done using the broth dilution method. The results showed that the extract at a concentration of 1% had bacteriostatic effect, while extracts at concentrations of 2, 4, and 8% showed bactericidal activity. All cream formulas showed anti-acne activity and
met the requirements for microbial contamination testing. In terms of physical stability, all formulations met the standards. However, formulas I, II, and III did not meet the requirements of the pH test, while formulas V and VI did not meet the requirements of the spreadability test. The findings of this study reveal that the extract of longan seed provided inhibitory activity against Propionibacterium acnes, and the formula IV qualified for physical quality and microbial contamination tests, making it an effective anti-acne cream.
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