Phytochemical Screening, Antioxidant Activity and α‐Glucosidase Inhibitability of Bauhinia  blakeana Dunn Leaf and Flower Extracts from Vietnam

http://www.doi.org/10.26538/tjnpr/v7i4.11

Authors

  • Chen V. Tran Faculty of Traditional Medicine, University of Medicine and Pharmacy at Ho Chi Minh City, Ho Chi Minh City, Viet Nam
  • Tham M. Vo Faculty of Pharmacy, Hong Bang International University, Ho Chi Minh City, Vietnam
  • Phong T. Bui Faculty of Medicine, Hong Bang International University, Ho Chi Minh City, Vietnam
  • Duc N.P. Duong Faculty of Traditional Medicine, University of Medicine and Pharmacy at Ho Chi Minh City, Ho Chi Minh City, Viet Nam
  • Lam X.N. Duong Faculty of Pharmacy, University of Medicine and Pharmacy at Ho Chi Minh City, Ho Chi Minh City, Viet Nam
  • Diep Q. Dinh Institute of Applied Technology, Thu Dau Mot University, Binh Duong Province, Vietnam
  • Hien T.T. Nguyen Faculty of Pharmacy, Nguyen Tat Thanh University, Ho Chi Minh City, Vietnam

Keywords:

polyphenols, α‐glucosidase, phytoconstituents, Bauhinia  blakeana, antioxidant

Abstract

Bauhinia blakeana Dunn is traditionally used as vegetables, medicinal herbs to treat diseases, and ornamental trees. The current study was performed to evaluate the phytochemicals, total phenolic (TPC) and total flavonoid (TFC) contents, antioxidant activity, and α‐glucosidase inhibitability of Bblakeana leaf and flower from Vietnam. Qualitative phytochemical analysis showed positive results for carbohydrates, organic acids, carotenoids, steroids, cardiac glycosides, triterpenoids, saponins, flavonoids, and tannins. The TPC and TFC obtained from Bblakeana leaf were 99.81 ± 0.94 (mg GAE/g E) and 114.93 ± 1.06 (mg RE/g E), respectively, whereas they were 40.45 ± 0.50 (mg GAE/g E) and 59.61 ± 0.85 (mg RE/g E) from Bblakeana The DPPH radical scavenging capacity assay of the crude ethanolic extracts of Bblakeana leaf (IC50 = 266.52 ± 1.03 μg/mL; R2 = 0.9864) and flower (IC50 > 1000 μg/mL) was determined. The leaf and flower extracts showed significant α-glucosidase inhibitory activity with IC50 values of 61.88 ± 0.19 μg/mL (R2 = 0.9838), 190.79 ± 0.18μg/mL (R2 = 0.9891), respectively. These results indicated that the extract of Bblakeana leaf and flower can be a promising candidate for alternative drug or functional food discovery, and nutritional recommendations for the control of oxidative stress and diabetes.

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Published

2023-05-01

How to Cite

Tran, C. V., Vo, T. M., Bui, P. T., Duong, D. N., Duong, L. X., Dinh, D. Q., & Nguyen, H. T. (2023). Phytochemical Screening, Antioxidant Activity and α‐Glucosidase Inhibitability of Bauhinia  blakeana Dunn Leaf and Flower Extracts from Vietnam: http://www.doi.org/10.26538/tjnpr/v7i4.11. Tropical Journal of Natural Product Research (TJNPR), 7(4), 2737–2743. Retrieved from https://www.tjnpr.org/index.php/home/article/view/1876