Formulation of Microemulsions Containing Rambutan Peel Extract and Their Antibacterial Activities

http://www.doi.org/10.26538/tjnpr/v7i4.10

Authors

  • Pornsak Sriamornsak Faculty of Pharmacy, Silpakorn University, Nakhon Pathom 73000, Thailand
  • Arzu Polat Department of Pharmaceutical Technology, Faculty of Mathematics-Physics-Chemistry, Berliner Hochschule für Technik, 13353 Berlin, Germany
  • Wantanwa Krongrawa Faculty of Pharmacy, Silpakorn University, Nakhon Pathom 73000, Thailand
  • Anne Krüger-Genge Department of Biomaterials and Healthcare, Fraunhofer-Institute for Applied Polymer Research, 14476 Potsdam-Golm, Germany
  • Joachim Storsberg Department of Biomaterials and Healthcare, Fraunhofer-Institute for Applied Polymer Research, 14476 Potsdam-Golm, Germany
  • Tassilo Seidler Department of Life Science and Technology, Berliner Hochschule für Technik, 13353 Berlin, Germany
  • Mont Kumpugdee-Vollrath Department of Pharmaceutical Technology, Faculty of Mathematics-Physics-Chemistry, Berliner Hochschule für Technik, 13353 Berlin, Germany

Keywords:

cytotoxicity, antibacterial, extract, rambutan peel, microemulsion

Abstract

Nowadays, numerous pathogens have become increasingly resistant to antibiotics. To address this issue, it is important to undertake additional research to develop alternative antibacterial agents. The goal of this investigation was to fabricate microemulsions from rambutan (Nephelium lappaceum L.) peel extract and test their antibacterial activity. The cytotoxicity of the rambutan peel extract was studied. The other assessments were conducted on the visual, physical, and electrical properties of microemulsions, which include their appearance, phase separation, viscosity, and conductivity. Moreover, the research also examined the potential antibacterial effects of microemulsions against both gram-negative (Escherichia coli) and gram-positive (Staphylococcus aureus) bacteria by exploring their ability to inhibit bacterial growth. The findings indicated that even when the extract was used at the highest concentration (100 µg/mL), there were no cytotoxic effects on skin keratinocyte cells. Using the pseudoternary phase diagram, a blend of rosemary oil, water, and a combination of surfactant (Tween® 80) and co-surfactant (Ethanol) were employed to create microemulsions containing different quantities of rambutan peel extract. According to the results, a stable microemulsion was observed as the ratio of Tween® 80 and ethanol was higher than 38%. The microemulsions containing extract at concentrations of 1% w/w, 5% w/w, and 10% w/w were clear and transparent, with no phase separation. All formulations were physiochemically acceptable. Microemulsions containing 1% w/w – 10% w/w rambutan peel extracts were shown to be efficient in suppressing only gram-positive S. aureus

Author Biographies

Pornsak Sriamornsak, Faculty of Pharmacy, Silpakorn University, Nakhon Pathom 73000, Thailand

Academy of Science, The Royal Society of Thailand, Bangkok 10300, Thailand

Joachim Storsberg, Department of Biomaterials and Healthcare, Fraunhofer-Institute for Applied Polymer Research, 14476 Potsdam-Golm, Germany

Private University in the Principality of Liechtenstein (UFL), Faculty of Medicine, 9495 Triesen, Principality of Liechtenstein

 

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Published

2023-05-01

How to Cite

Sriamornsak, P., Polat, A., Krongrawa, W., Krüger-Genge, A., Storsberg, J., Seidler, T., & Kumpugdee-Vollrath, M. (2023). Formulation of Microemulsions Containing Rambutan Peel Extract and Their Antibacterial Activities: http://www.doi.org/10.26538/tjnpr/v7i4.10. Tropical Journal of Natural Product Research (TJNPR), 7(4), 2730–2736. Retrieved from https://www.tjnpr.org/index.php/home/article/view/1872

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