The Potential Role of Vitamin D Administration in The Skin Aging Process Through The Inflammatory Pathway: A Systematic Review http://www.doi.org/10.26538/tjnpr/v7i4.1
Main Article Content
Skin aging occurs through various mechanisms, including the inflammatory process. Wrinkled and dry skin in the elderly is correlated with deficiency of vitamin D. Maintaining vitamin D at normal levels can suppress the degeneration process including skin aging. This study aimed to conduct a review regarding the effect of vitamin D administration on the skin, particularly on the inflammatory process. This review was conducted using the search engine namely Pubmed, Google Scholar, and Science Direct. The inclusion criteria included original articles, of both in vivo and in vitro studies, published in 2012-2022. A total of eight articles were obtained using the keywords namely inflammation, vitamin D, and aging. The findings demonstrate that vitamin D can reduce inflammation in the skin by reducing collagen breakdown, inhibiting high inflammatory response, and modulating activity immune response, as well as through its photoprotective effect. Vitamin D reduces collagen breakdown by decreasing MMP-1. Vitamin D suppresses inflammatory response by inhibiting the expression of inflammatory cytokines and decreasing the expression of growth factors. Vitamin D modulates activity related to immune response by increasing the percentage of Treg cells. Vitamin D has a photoprotective effect, which reduces thymine dimer by reducing nitric oxide and its products and increases the level of anti inflammatory mediator. Inhibition of the expression of growth factors, proinflammatory cytokines, increased level of the anti-inflammatory mediator, following Vitamin D supplementation is associated with skin barrier repair. Thus, vitamin D regulates an anti inflammatory pathway that may be exploited to slow the degradation process in skin aging.
This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.
UN. World Population Ageing 2019 [Internet]. World Population Ageing 2019. 2019. 64 p. Available from: http://www.un.org/esa/population/publications/worldageing19502050/pdf/65executivesummary spanish.pdf%0Ahttp://link.springer.com/chapter/10.1007/978-94-007-5204-7_6
Zhang S, Duan E. Fighting against Skin Aging: The Way from Bench to Bedside. Cell Transplant. 2018;27(5):729–38.
Almeida AJPO De, Ribeiro TP, Medeiros IA De. Aging: Molecular Pathways and Implications on the Cardiovascular System. Oxid Med Cell Longev. 2017;2017.
Kang S, editor. 9 thFitzpatrick’s Dermatology 9th Edition, 2-Volume Set.pdf. 9th ed. Chicago; 2019.
Kim K, Kim J, Kim H, Sung GY. Effect of α-lipoic acid on the development of human skin equivalents using a pumpless skin-on-a-chip model. Int J Mol Sci. 2021;22(4):1–19.
Stanley A, Hynes A, Brakebusch C, Quondamatteo F. Rho GTPases and Nox dependent ROS production in skin. Is there a connection? Histol Histopathol. 2012;27(11):1395–406.
Parrado C, Mercado-Saenz S, Perez-Davo A, Gilaberte Y, Gonzalez S, Juarranz A. Environmental Stressors on Skin Aging. Mechanistic Insights. Front Pharmacol. 2019;10(July):1–17.
Kim SR, Jung YR, An HJ, Kim DH, Jang EJ, Choi YJ. AntiWrinkle and Anti-Inflammatory Effects of Active Garlic Components and the Inhibition of MMPs via NF-κB Signaling. PLoS One. 2013;8(9):1–12.
Miyoshi K, Takaishi M, DiGiovanni J, Sano S. Ultraviolet B irradiation induces the expression of IL-33 mRNA and protein in normal human epidermal keratinocytes. J Dermatol Sci. 2012;65(1):72–4.
Chambers ES, Vukmanovic-Stejic M. Skin barrier immunity and ageing. Immunology. 2020;160(2):116–25.
Liu Q, Dwyer GK, Zhao Y, Li H, Mathews LR, Chakka AB. IL-33–mediated IL-13 secretion by ST2+ Tregs controls inflammation after lung injury. JCI Insight. 2019;4(6):9–17.
Schagen SK, Zampeli VA, Makrantonaki E, Zouboulis CC. Discovering the link between nutrition and skin aging. Dermatoendocrinol. 2012;4(3): 298–307.
Bocheva G, Slominski RM, Slominski AT. The impact of vitamin d on skin aging. Int J Mol Sci. 2021;22(16):1–18.
Stefan J, Blawat P, Bartoszewska-Kubiak A, Szamocka M, Roszkowski K. Novel vitamin D3-hydroxyderivatives as candidates for the therapy against skin-aging and photoaging: bioinformatical analysis. Med Res J. 2021;6(3):254–69.
Martínez-Miguel P, Valdivielso JM, Medrano-Andrés D, Román-García P, Cano-Peñalver JL, Rodríguez-Puyol M, et al. The active form of vitamin D, calcitriol, induces a complex dual upregulation of endothelin and nitric oxide in cultured endothelial cells. Am J Physiol - Endocrinol Metab. 2014;307(12):E1085–96.
Beckett E. More than bone health: The many roles for vitamin D. Nutrients. 2020;12(8):1–3.
Berridge MJ. Vitamin D deficiency accelerates ageing and age-related diseases: a novel hypothesis. J Physiol. 2017;595(22):6825–36.
Yin K, Agrawal DK. Vitamin D and inflammatory diseases. J Inflamm Res. 2014;7(1):69–87.
Elizondo-Montemayor L, Castillo EC, Rodríguez-López C, Villarreal-Calderón JR, Gómez-Carmona M, TenorioMartínez S. Seasonal Variation in Vitamin D in Association with Age, Inflammatory Cytokines, Anthropometric Parameters, and Lifestyle Factors in Older Adults. Mediators
Inflamm. 2017;2017: 1-15.
Boucher O, Muckle G, Jacobson JL, Carter RC, Kaplanestrin M, Ayotte P. Domain-Specific Effects of Prenatal Exposure to PCBs , Mercury , and Lead on Infant Cognition : Results from the Environmental Contaminants and Child Development Study in Nunavik. Environ Health Perspect. 2014;(3):310–6.
Bi Y, Xia H, Li L, Lee RJ, Xie J, Liu Z. Liposomal vitamin D3 as an anti-aging agent for the skin. Pharmaceutics. 2019;11(7): 1-12.
Song EJ, Gordon-Thomson C, Cole L, Stern H, Halliday GM, Damian DL. 1α,25-Dihydroxyvitamin D3 reduces several types of UV-induced DNA damage and contributes to photoprotection. J Steroid Biochem Mol Biol. 2013;136(1):131–8.
Gorman S, Geldenhuys S, Judge M, Weeden CE, Waithman J, Hart PH. Dietary Vitamin D Increases Percentages and Function of Regulatory T Cells in the Skin-Draining Lymph Nodes and Suppresses Dermal Inflammation. J Immunol Res. 2016;2016.
Scott JF, Das LM, Ahsanuddin S, Qiu Y, Binko AM, Traylor ZP. Oral Vitamin D Rapidly Attenuates Inflammation from Sunburn: An Interventional Study. J Invest Dermatol. 2017;137(10):2078–86.
Philips N, Ding X, Kandalai P, Marte I, Krawczyk H, Richardson R. The Beneficial Regulation of Extracellular Matrix and Heat Shock Proteins, and the Inhibition of Cellular Oxidative Stress Effects and Inflammatory Cytokines by 1α, 25 dihydroxyvitaminD3 in Non-Irradiated and Ultraviolet Radiated Dermal Fibroblasts Neena. Cosmetics. 2019;6(46):9–12.
Philips N, Samuel P, Keller T, Alharbi A, Alshalan S, Shamlan S-A. Beneficial Regulation of Cellular Oxidative Stress Effects, and Expression of Inflammatory, Angiogenic, and the Extracellular Matrix Remodeling Proteins by 1α,25-Dihydroxyvitamin D3 in a
Lopez D V., Al-Jaberi FAH, Damas ND, Weinert BT, Pus U, Torres-Rusillo S. Vitamin D Inhibits IL-22 Production Through a Repressive Vitamin D Response Element in the il22 Promoter. Front Immunol. 2021;12(August):1–12.
Pizzino G, Irrera N, Cucinotta M, Pallio G, Mannino F, Arcoraci V. Oxidative Stress: Harms and Benefits for Human Health. Oxid Med Cell Longev. 2017;2017.
Hingert D, Nawilaijaroen P, Ekström K, Baranto A, Brisby H. Human Levels of MMP-1 in Degenerated Disks Can Be Mitigated by Signaling Peptides from Mesenchymal Stem Cells. Cells Tissues Organs. 2020;209(2–3):144–53.
Pittayapruek P, Meephansan J, Prapapan O, Komine M, Ohtsuki M. Role of matrix metalloproteinases in Photoaging and photocarcinogenesis. Int J Mol Sci. 2016;17(6).
Lago JC, Puzzi MB. The effect of aging in primary human dermal fibroblasts. PLoS One. 2019;14(7):1–14.
Samanta S. Vitamin D and immunomodulation in the skin: a useful affirmative nexus. Explor Immunol. 2021;90–111.
Calton EK, Keane KN, Newsholme P, Soares MJ. The impact of Vitamin D levels on inflammatory status: A systematic review of immune cell studies. PLoS One. 2015;10(11):1–12.
Almerighi C, Sinistro A, Cavazza A, Ciaprini C, Rocchi G, Bergamini A. 1alpha, 25-dihydroxyvitamin D3 inhibits CD40L-induced pro-inflammatory and immunomodulatory activity in human monocytes. Cytokine. 2009;45:190–7.
Toniato E, Spinas E, Saggini A, Kritas SK, Caraffa A, Antinolfi P. Immunomodulatory Effects of Vitamin D on Skin Inflammation. J Biol Regul Homeost Agents. 2015;29(3):563–7.
Ansary TM, Hossain MR, Kamiya K, Komine M, Ohtsuki M. Inflammatory molecules associated with ultraviolet radiation‐mediated skin aging. Int J Mol Sci. 2021;22(8): 1-14
Hata TR, Audish D, Kotol P, Coda A, Kabigting F, Miller J. A randomized controlled double-blind investigation of the effects of vitamin D dietary supplementation in subjects with atopic dermatitis. J Eur Acad Dermatology Venereol. 2014;28(6):781–9.
Fleet JC, Aldea D, Chen L, Christakos S, Verzi M. Regulatory domains controlling high intestinal vitamin D receptor gene expression are conserved in mouse and human. J Biol Chem. 2022;298(3):101616.
Sirajudeen S, Shah I, Al Menhali A. A narrative role of vitamin d and its receptor: With current evidence on the gastric tissues. Int J Mol Sci. 2019;20(15).
Segaert S, De Haes P, Bouillon R. The Epidermal Vitamin D System. Biol Eff Light 2001. 2002;(2):245–53.
Di Rosa M, Castrogiovanni P, Trovato FM, Malatino L, Ravalli S, Imbesi R. Adapted moderate training exercise decreases the expression of NGAL in the rat kidney: An immunohistochemical study. Appl Sci. 2019;9(6).
Douki T, von Koschembahr A, Cadet J. Insight in DNA Repair of UV-induced Pyrimidine Dimers by Chromatographic Methods. Photochem Photobiol. 2017;93(1):207–15.
Moretto J, Girard C, Demougeot C. The role of arginase in aging: A systematic review. Exp Gerontol. 2019;116(October 2018):54–73.
Dawoud NM, Bakry OA, Shoeib MA, Ismael HN. Serum Vitamin D and facial aging: Is there a link? Skin Pharmacol Physiol. 2016;29(2):76–82.
Philips N, Portillo-Esnaola M, Samuel P, Gallego-Rentero M, Keller T, Franco J. Anti-aging and anti-carcinogenic effects of 1α, 25-dihyroxyvitamin D3 on skin. Plast Aesthetic Res. 2022; 9:4: 1-10
Xu H, Zheng Y-W, Liu Q, Liu L-P, Luo F-L, Zhou H-C. Reactive Oxygen Species in Skin Repair, Regeneration, Aging, and Inflammation. React Oxyg Species Living Cells. 2018: 69-87