Aerial Parts of Euphorbia hirta L. in Polar and Non-Polar Solvents: Phytochemical, Antioxidant and Glucose Uptake Studies for Potential Source of Adjunct Drug for Diabetes doi.org/10.26538/tjnpr/v4i10.9

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Published: Oct 1, 2020
Keywords:
Polyphenol, Flavonoid, Euphorbia hirta, Antioxidant, Antidiabetic

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Levent B. B. Aquino
School of Chemical, Biological, and Materials Engineering, and Sciences, Mapúa University, Intramuros, Manila, 1002 Metro Manila, Philippines
Marjette Y. U. Barbaza
School of Chemical, Biological, and Materials Engineering, and Sciences, Mapúa University, Intramuros, Manila, 1002 Metro Manila, Philippines
Judson L. T. Ramos
School of Chemical, Biological, and Materials Engineering, and Sciences, Mapúa University, Intramuros, Manila, 1002 Metro Manila, Philippines
Mon-Juan Lee
Department of Bioscience Technology, College of Health Sciences, Chang Jung Christian University, Tainan 711, Taiwan
Shun-Yao Ko
Graduate Institute of Medical Sciences, College of Health Sciences, Chang Jung Christian University, Tainan 711, Taiwan
Chieh-Lun Hsieh
Ph.D. Educational Management Major in P.E., Graduate School, Emilio Aguinaldo College, Manila, 1007 Metro Manila, Philippines
Kathlia A. De Castro-Cruz
School of Chemical, Biological, and Materials Engineering, and Sciences, Mapúa University, Intramuros, Manila, 1002 Metro Manila, Philippines
Po-Wei Tsai
Department of Medical Sciences Industry, College of Health Sciences, Chang Jung Christian University, Tainan 711, Taiwan

Abstract

Euphorbia hirta L. (Euphorbiaceae) is an herbal plant found in countries with tropical and subtropical climates. It contains biologically active components that have pharmacological properties related to progression of oxidative stress and hyperglycemia. In this study, the dried aerial parts of the plant were refluxed using different polar and non-polar solvents such as water, methanol, ethanol, acetone, ethyl acetate, dichloromethane, and hexane. The effect of solvents used during extraction on the number of phytochemicals, antioxidant properties using DPPH and FRAP assays as well as on the glucose uptake were investigated. Results showed that all extracts using various solvents have varied phytochemical contents while polar solvents exhibited higher antioxidant properties both in DPPH and FRAP assays. Likewise, glucose uptake results showed that extracts from water have higher glucose uptake compared to the commercial drug metformin. Thus, components from the water extract of E. hirta L. could be a potential adjunct drug for diabetes.

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Aquino, L. B. B., Barbaza, M. Y. U., Ramos, J. L. T., Lee, M.-J., Ko, S.-Y., Hsieh, C.-L., Castro-Cruz, K. A. D., & Tsai, P.-W. (2020). Aerial Parts of Euphorbia hirta L. in Polar and Non-Polar Solvents: Phytochemical, Antioxidant and Glucose Uptake Studies for Potential Source of Adjunct Drug for Diabetes: doi.org/10.26538/tjnpr/v4i10.9. Tropical Journal of Natural Product Research (TJNPR), 4(10), 708-713. https://www.tjnpr.org/index.php/home/article/view/1021
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Vol. 4 No. 10 (2020): Tropical Journal of Natural Product Research
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Articles
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This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.

How to Cite

Aquino, L. B. B., Barbaza, M. Y. U., Ramos, J. L. T., Lee, M.-J., Ko, S.-Y., Hsieh, C.-L., Castro-Cruz, K. A. D., & Tsai, P.-W. (2020). Aerial Parts of Euphorbia hirta L. in Polar and Non-Polar Solvents: Phytochemical, Antioxidant and Glucose Uptake Studies for Potential Source of Adjunct Drug for Diabetes: doi.org/10.26538/tjnpr/v4i10.9. Tropical Journal of Natural Product Research (TJNPR), 4(10), 708-713. https://www.tjnpr.org/index.php/home/article/view/1021

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