In Vitro Cytotoxic Activity of Constituents of the Aerial Parts of Glycosmis parviflora

Phu Q. D. Nguyen1, Hoai T. Nguyen1, Linh T. K. Nguyen1, Hung Q. Vo1, Anh T. Le2, Thao T. Do3, Duc V. Ho1*
1Faculty of Pharmacy, Hue University of Medicine and Pharmacy, Hue University, 06 Ngo Quyen, Hue City, Vietnam
2Quang Tri Center of Science and Technology, Mientrung Institute for Scientific Research, VAST, Dien Bien Phu, Dong Ha, Quang Tri, Vietnam
3Institute of Biotechnology, Vietnam Academy of Science and Technology, Hanoi, Vietnam

Corresponding Author: [email protected]; Tel: +84-905-974-785
Recieved Date: August 12, 2020; Accepted Date: October 28, 2020; Published Date: 02 November 2020
Citation: Nguyen PQD, Nguyen HT1, Nguyen LTK, Vo HQ, Le AT, Do TT, Ho DV.  In Vitro Cytotoxic Activity of Constituents of the Aerial Parts of Glycosmis parviflora. Trop J Nat Prod Res. 2020; 4(10):703-707.
Copyright: © 2020 Nguyen et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

Glycosmis parviflora (Sims) Little is used in Vietnamese ethnomedicine to treat several ailments. We investigated the aerial parts of G. parviflora and obtained three triterpenes, a sesquiterpene, and a flavonoid C-glycoside. The terpenes were friedelin, arborinol, isoarborinol, and spathulenol, and the glycoside was vitexin. The compounds were identified by one- and two-dimensional nuclear magnetic resonance spectroscopy and by comparison with previous reports. Spathulenol exhibited moderate cytotoxic activity against LU-1, MDA-MB-231, MKN7, HepG2, and HeLa human cancer cells with 50% inhibitory concentration (IC50) values ranging from 31.88 to 42.33 µg/mL. Therefore, G. parviflora and spathulenol might be useful for developing novel anticancer agents.

Keywords: Triterpene, Sesquiterpene, Flavonoid, Spathulenol, Cytotoxicity, Vietnam.
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